USP2

Gene Symbol	USP2
Entrez Gene	9099
Alt Symbol	UBP41, USP9
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 2
Other Description	41 kDa ubiquitin-specific protease|deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 2|ubiquitin specific protease 12|ubiquitin specific protease 9|ubiquitin thioesterase 2|ubiquitin-specific-processing protease 2
Swissprots	Q96MB9 Q8IW04 B0YJB8 Q8IUM2 Q9BQ21 E9PPM2 O75604
Accessions	ACA06096 ACA06097 EAW67484 EAW67485 EAW67486 O75604 AF079564 AAC28392 AF440755 AAN65363 AI806430 AK057225 BAB71388 AK292255 BAF84944 AK301805 BAH13558 AK309582 BC002854 AAH02854 BC002955 AAH02955 BC041366 AAH41366 DB065104 DB088349 DB098786 DQ892532 ABM83458 DQ895743 ABM86669 XM_005271721 XP_005271778 XM_005271722 XP_005271779 NM_001243759 NP_001230688 NM_004205 NP_004196 NM_171997 NP_741994
Function	Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By simil
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}.
Tissue Specificity	Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269|PubMed:20403044}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

USP2-Over-expression-Lysate - LY10968a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

USP2 293T Cell Transient Overexpression Lysate(Denatured) - H00009099-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

USP2 overexpression lysate - LY401351 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

USP2 overexpression lysate - LY403527 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

USP2 293 Cell Lysate - 403050 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

USP2 Overexpression Lysate (Denatured) - H00009099-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

USP2 Overexpression Lysate (Native) - NBL1-17650 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

USP2 Over-expression Lysate Product - GWB-22D8E7 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

USP2 Overexpression Lysate (Native) - NBP2-04268 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

USP2 Overexpression Lysate (Denatured) - H00009099-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

USP2 knockout Cell lysate - LC810862 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human USP2 Knockdown Stable Cell Line - CSC-DC017163 from Creative biogene Category Cell Line Species Human

Human USP2 Knockout Cell Line-HeLa - CSC-RT0847 from Creative biogene Category Cell Line Species Human

USP2 KO Cell Lysate-HeLa - CLKO-0350 from Creative biogene Category Cell Lysate

Search more