USP2

Gene Symbol	USP2
Entrez Gene	9099
Alt Symbol	UBP41, USP9
Species	Human
Gene Type	protein-coding
Description	ubiquitin specific peptidase 2
Other Description	41 kDa ubiquitin-specific protease|deubiquitinating enzyme 2|ubiquitin carboxyl-terminal hydrolase 2|ubiquitin specific protease 12|ubiquitin specific protease 9|ubiquitin thioesterase 2|ubiquitin-specific-processing protease 2
Swissprots	Q96MB9 Q8IW04 B0YJB8 Q8IUM2 Q9BQ21 E9PPM2 O75604
Accessions	ACA06096 ACA06097 EAW67484 EAW67485 EAW67486 O75604 AF079564 AAC28392 AF440755 AAN65363 AI806430 AK057225 BAB71388 AK292255 BAF84944 AK301805 BAH13558 AK309582 BC002854 AAH02854 BC002955 AAH02955 BC041366 AAH41366 DB065104 DB088349 DB098786 DQ892532 ABM83458 DQ895743 ABM86669 XM_005271721 XP_005271778 XM_005271722 XP_005271779 NM_001243759 NP_001230688 NM_004205 NP_004196 NM_171997 NP_741994
Function	Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By simil
Subcellular Location	Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}.
Tissue Specificity	Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level). {ECO:0000269|PubMed:20403044}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human USP2 full length protein - ab198439 from Abcam Category Protein Prices $474.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Active human USP2 protein fragment - ab125735 from Abcam Category Protein Source E. coli Species Human

Active human USP2 protein fragment - ab188722 from Abcam Category Protein Prices $243.00 Sizes 50 µg Source E. coli Species Human

Active human USP2 protein fragment - ab188724 from Abcam Category Protein Prices $243.00 Sizes 50 µg Source E. coli Species Human

Human USP2 peptide - ab66555 from Abcam Category Peptide

USP2 Antibody Blocking Peptide - LS-E29467 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP2 Antibody Blocking Peptide - LS-E29423 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP2 Antibody Blocking Peptide - LS-E29424 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

USP2 Antibody Blocking Peptide - LS-E21699 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP2 Antibody Blocking Peptide - LS-E21700 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP2 Antibody Blocking Peptide - LS-E6875 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP2 Antibody Blocking Peptide - LS-E6876 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP2 Antibody Blocking Peptide - LS-E6877 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

USP2 Peptide - P0916 from Novus Biologicals Category Peptide Species Human

USP2 Peptide - P0915 from Novus Biologicals Category Peptide Species Human

USP2-Antibody-C-term-L523-Blocking-Peptide - BP2131c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP2-Antibody-C-term-Blocking-Peptide - BP2131b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

USP2-Antibody-N-term-Blocking-Peptide - BP2131a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-USP2 Catalytic Domain, CF - E-506-050 from R&D Systems Category Protein Source E. coli-derived, Contains a C-terminal 6-His tag

Recombinant Human USP2 Catalytic Domain, CF - E-504-050 from R&D Systems Category Protein Source E. coli-derived,

USP2 Blocking Peptide - 33R-5126 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP2 Blocking Peptide - 33R-6679 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

USP2 fusion protein - Ag7658 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

USP2 fusion protein - ag7741 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

USP2 fusion protein - ag0591 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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