| Gene Symbol |
DUSP26
|
| Entrez Gene |
78986
|
| Alt Symbol |
DSP-4, DUSP24, LDP-4, MKP-8, MKP8, NATA1, NEAP, SKRP3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dual specificity phosphatase 26 (putative)
|
| Other Description |
MAP kinase phosphatase 8|Novel amplified gene in thyroid anaplastic cancer|dual specificity phosphatase SKRP3|dual specificity protein phosphatase 26|low-molecular-mass dual-specificity phosphatase 4|mitogen-activated protein kinase phosphatase 8|neuroendocrine-associated phosphatase
|
| Swissprots |
D3DSV8 Q9BV47 Q9BTW0
|
| Accessions |
EAW63392 EAW63393 EAW63394 Q9BV47 AB103376 BAD91015 AB158288 BAD82942 AB237597 BAE46506 AK055704 BAB70991 AY902194 AAX07132 BC001613 AAH01613 BC003115 AAH03115 BC067804 AAH67804 BI753746 BI834891 BP196801 DA132743 HQ447174 ADQ31661 XM_005273633 XP_005273690 NM_001305115 NP_001292044 NM_001305116 NP_001292045 NM_024025 NP_076930
|
| Function |
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Golgi apparatus.
|
| Tissue Specificity |
Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}.
|