Gene Symbol | DUSP26 |
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Entrez Gene | 78986 |
Alt Symbol | DSP-4, DUSP24, LDP-4, MKP-8, MKP8, NATA1, NEAP, SKRP3 |
Species | Human |
Gene Type | protein-coding |
Description | dual specificity phosphatase 26 (putative) |
Other Description | MAP kinase phosphatase 8|Novel amplified gene in thyroid anaplastic cancer|dual specificity phosphatase SKRP3|dual specificity protein phosphatase 26|low-molecular-mass dual-specificity phosphatase 4|mitogen-activated protein kinase phosphatase 8|neuroendocrine-associated phosphatase |
Swissprots | D3DSV8 Q9BV47 Q9BTW0 |
Accessions | EAW63392 EAW63393 EAW63394 Q9BV47 AB103376 BAD91015 AB158288 BAD82942 AB237597 BAE46506 AK055704 BAB70991 AY902194 AAX07132 BC001613 AAH01613 BC003115 AAH03115 BC067804 AAH67804 BI753746 BI834891 BP196801 DA132743 HQ447174 ADQ31661 XM_005273633 XP_005273690 NM_001305115 NP_001292044 NM_001305116 NP_001292045 NM_024025 NP_076930 |
Function | Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}. |
Subcellular Location | Cytoplasm. Nucleus. Golgi apparatus. |
Tissue Specificity | Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer. {ECO:0000269|PubMed:15796912, ECO:0000269|PubMed:16581800, ECO:0000269|PubMed:16924234, ECO:0000269|PubMed:17001450}. |
Human DUSP26 full length protein - ab171697 from Abcam
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MKP-8 / DUSP26 Antibody Blocking Peptide - LS-E29179 from LifeSpan Bioscience
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MKP-8 / DUSP26 Antibody Blocking Peptide - LS-E29181 from LifeSpan Bioscience
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MKP-8 / DUSP26 Antibody Blocking Peptide - LS-E29180 from LifeSpan Bioscience
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MKP-8 / DUSP26 Antibody Blocking Peptide - LS-E29182 from LifeSpan Bioscience
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Human DUSP26 protein - orb246629 from Biorbyt
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DUSP26 protein (His tag) - 80R-3030 from Fitzgerald
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DUSP26 (1-211, His-tag) - AR51148PU-N from Acris Antibodies
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DUSP26 (1-211, His-tag) - AR51148PU-S from Acris Antibodies
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DUSP26 - H00078986-P01 from Acris Antibodies
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DUSP26 - H00078986-Q01-10 from Acris Antibodies
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DUSP26 - H00078986-Q01-25 from Acris Antibodies
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DUSP26, 1-211aa, Human, His tag, E.coli - 01-P2324 from ARP American Research Products
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DUSP26 fusion protein - ag7831 from Proteintech Group
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DUSP26 fusion protein - Ag7974 from Proteintech Group
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DUSP26, 1-211aa, Human, His tag, E.coli - GWB-ATG507 from Genway Biotech
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Recombinant Human DUSP26, His-tagged - DUSP26-26910TH from Creative Biomart
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Recombinant Human CD7, His-tagged - DUSP26-2324H from Creative Biomart
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Recombinant Human Dual specificity protein phosphatase 26(DUSP26) - CSB-YP863128HU CSB-BP863128HU CSB-MP863128HU from Cusabio
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Recombinant human Dual specificity protein phosphatase 26 - CSB-EP863128HU from Cusabio
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DuSP26, 1-211aa, Human, His tag, E.coli (Denatured) - ATGP2324 from ATGen
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DUSP26-Antibody-Center-Blocking-peptide - BP10157c from Abgent, a WuXi AppTec company
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DUSP26 Recombinant Protein (OPCA02463) - OPCA02463 from Aviva Systems Biology
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Human Dual Specificity Protein Phosphatase 26 (DUSP26) - PHD32324 from AssayPro
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Dual Specificity Phosphatase 26, Human Recombinant - 228-20694-1 from RayBiotech
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