RNF4

Gene Symbol	RNF4
Entrez Gene	6047
Alt Symbol	RES4-26, SLX5, SNURF
Species	Human
Gene Type	protein-coding
Description	ring finger protein 4
Other Description	E3 ubiquitin ligase RNF4|E3 ubiquitin-protein ligase RNF4|small nuclear RING finger protein
Swissprots	D6RF58 P78317 Q49AR8 B2R6D6
Accessions	EAW82522 EAW82523 EAW82524 EAW82525 EAW82526 P78317 AB000468 BAA19122 AK128038 BAG54620 AK307372 AK309509 AK311314 AK312534 BAG35433 BC031935 AAH31935 BU682428 CB993989 DA342512 DB064628 EU446651 ABZ92180 U95140 AAC52022 NM_001185009 NP_001171938 NM_001185010 NP_001171939 NM_002938 NP_002929
Function	E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:2021
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Tissue Specificity	Widely expressed at low levels in many tissues; highly expressed in testis. {ECO:0000269|PubMed:9479498}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF4 Ubiquitin Ligase Kit - di-SUMO3 Substrate - K-220 from R&D Systems Prices $325.00 Sizes 1 kit

Ring Finger Protein 4, RNF4, Human, ELISA Kit - E-EL-H1415 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Mouse, ELISA Kit - E-EL-M1024 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Rat, ELISA Kit - E-EL-R0860 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Rabbit, ELISA Kit - E-EL-RB0486 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Chicken, ELISA Kit - E-EL-Ch1819 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Porcine, ELISA Kit - E-EL-P0214 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Guinea Pig, ELISA Kit - E-EL-GP1283 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Ring Finger Protein 4, RNF4, Monkey, ELISA Kit - E-EL-MK0596 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human RNF4 ELISA Kit - HR0073 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine RNF4 ELISA Kit - AR0073 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Ring Finger Protein 4, ELISA Kit - MBS038145 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS034306 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS066055 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS028687 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS742179 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS723499 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS726319 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS011835 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS044861 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS032586 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ring Finger Protein 4, ELISA Kit - MBS729934 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ring finger protein 4, ELISA Kit - MBS9340249 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human RNF4(Ring Finger Protein 4) ELISA Kit - E-EL-H1415 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Ring Finger Protein 4, ELISA Kit - MBS729706 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

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