RNF4

Gene Symbol RNF4
Entrez Gene 6047
Alt Symbol RES4-26, SLX5, SNURF
Species Human
Gene Type protein-coding
Description ring finger protein 4
Other Description E3 ubiquitin ligase RNF4|E3 ubiquitin-protein ligase RNF4|small nuclear RING finger protein
Swissprots D6RF58 P78317 Q49AR8 B2R6D6
Accessions EAW82522 EAW82523 EAW82524 EAW82525 EAW82526 P78317 AB000468 BAA19122 AK128038 BAG54620 AK307372 AK309509 AK311314 AK312534 BAG35433 BC031935 AAH31935 BU682428 CB993989 DA342512 DB064628 EU446651 ABZ92180 U95140 AAC52022 NM_001185009 NP_001171938 NM_001185010 NP_001171939 NM_002938 NP_002929
Function E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:2021
Subcellular Location Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Tissue Specificity Widely expressed at low levels in many tissues; highly expressed in testis. {ECO:0000269|PubMed:9479498}.

RNF4 CRISPR/Cas9 KO Plasmid (h) - sc-403964 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 HDR Plasmid (h) - sc-403964-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 Double Nickase Plasmid (h) - sc-403964-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 Double Nickase Plasmid (h2) - sc-403964-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 CRISPR Activation Plasmid (h) - sc-403964-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 CRISPR Activation Plasmid (h2) - sc-403964-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 Lentiviral Activation Particles (h) - sc-403964-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 Lentiviral Activation Particles (h2) - sc-403964-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF4 siRNA (h) - sc-38236 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF4 shRNA Plasmid (h) - sc-38236-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF4 shRNA (h) Lentiviral Particles - sc-38236-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF4 RNAi - H00006047-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU109631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18435 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18435 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13209 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13209

RNF4 siRNA (Human) - CRH4094 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF4 - MBS8208169 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF4 (NM_002938.4) - SHH397336 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF4 siRNA - orb264596 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF4 shRNA Plasmid (Human) - CHH4094 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF4 miRNA 3'UTR clone - MiUTR4H-TG07552 from Creative biogene

Species Reactivities Human
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