RNF4

Gene Symbol	RNF4
Entrez Gene	6047
Alt Symbol	RES4-26, SLX5, SNURF
Species	Human
Gene Type	protein-coding
Description	ring finger protein 4
Other Description	E3 ubiquitin ligase RNF4|E3 ubiquitin-protein ligase RNF4|small nuclear RING finger protein
Swissprots	D6RF58 P78317 Q49AR8 B2R6D6
Accessions	EAW82522 EAW82523 EAW82524 EAW82525 EAW82526 P78317 AB000468 BAA19122 AK128038 BAG54620 AK307372 AK309509 AK311314 AK312534 BAG35433 BC031935 AAH31935 BU682428 CB993989 DA342512 DB064628 EU446651 ABZ92180 U95140 AAC52022 NM_001185009 NP_001171938 NM_001185010 NP_001171939 NM_002938 NP_002929
Function	E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:2021
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Tissue Specificity	Widely expressed at low levels in many tissues; highly expressed in testis. {ECO:0000269|PubMed:9479498}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF4 full length protein - ab134611 from Abcam Category Protein Source E. coli Species Human

RNF4 Antibody Blocking Peptide - LS-E4053 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF4 Recombinant Protein - H00006047-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RNF4 Partial Recombinant Protein - H00006047-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human RNF4 Protein - NBP2-23441 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

RNF4-Antibody-C-term-Blocking-Peptide - BP16278b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human RNF4, CF - E3-210-050 from R&D Systems Category Protein Source E. coli-derived,

Human RNF4 protein - orb169202 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

RNF4 (1-190, His-tag) - AR50585PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

RNF4 (1-190, His-tag) - AR50585PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

RNF4 - H00006047-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF4 - H00006047-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF4 - H00006047-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF4 - H00006047-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF4, 1-190aa, Human, His tag, E.coli - 01-P1761 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

RNF4 fusion protein - Ag12115 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

RNF4, 1-190aa, Recombinant Protein - GWB-P0277D from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Ring Finger Protein 4, His-tagged - RNF4-7193H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF4(RNF4) - CSB-YP019889HU CSB-EP019889HU CSB-BP019889HU CSB-MP019889HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF4, 1-190aa, Human, His tag, E.coli - ATGP1761 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Recombinant Human RNF4 Protein, CF - E3-210 from R&D Systems Category Protein Prices $269.00 Sizes 50 µg Source E. coli -derived Species Human

RNF4 - E3-210 from Boston Biochem Prices $269.00 Sizes 50 µg

RNF4 Recombinant Protein Antigen - NBP2-13243PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF4 Peptide, Human - M34GP13437H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF4 - PAT-81762-1 from Nordic BioSite Category Protein Species Human

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