RNF4

Gene Symbol	RNF4
Entrez Gene	6047
Alt Symbol	RES4-26, SLX5, SNURF
Species	Human
Gene Type	protein-coding
Description	ring finger protein 4
Other Description	E3 ubiquitin ligase RNF4|E3 ubiquitin-protein ligase RNF4|small nuclear RING finger protein
Swissprots	D6RF58 P78317 Q49AR8 B2R6D6
Accessions	EAW82522 EAW82523 EAW82524 EAW82525 EAW82526 P78317 AB000468 BAA19122 AK128038 BAG54620 AK307372 AK309509 AK311314 AK312534 BAG35433 BC031935 AAH31935 BU682428 CB993989 DA342512 DB064628 EU446651 ABZ92180 U95140 AAC52022 NM_001185009 NP_001171938 NM_001185010 NP_001171939 NM_002938 NP_002929
Function	E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. {ECO:0000269|PubMed:12885770, ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:19307308, ECO:0000269|PubMed:20026589, ECO:0000269|PubMed:2021
Subcellular Location	Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Tissue Specificity	Widely expressed at low levels in many tissues; highly expressed in testis. {ECO:0000269|PubMed:9479498}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RNF4 overexpression lysate - LY419002 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RNF4 293 Cell Lysate - 408887 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RNF4 Overexpression Lysate (Native) - NBL1-15454 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RNF4 Over-expression Lysate Product - GWB-D4D928 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

RNF4 Overexpression Lysate (Native) - NBP2-10244 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human RNF4 Knockdown Stable Cell Line - CSC-DC013437 from Creative biogene Category Cell Line Species Human

Human RNF4 Knockout Cell Line-HeLa - CSC-RT1606 from Creative biogene Category Cell Line Species Human

RNF4 KO Cell Lysate-HeLa - CLKO-1453 from Creative biogene Category Cell Lysate

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