ANGPTL4

Gene Symbol	ANGPTL4
Entrez Gene	51129
Alt Symbol	ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158
Species	Human
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
Swissprots	B4E089 Q9BY76 Q9Y5B3 Q53HQ6 D6W670 Q53HU1 A8MY84 Q6UXN0 Q9NZU4 Q9HBV4 F5H0I2
Accessions	EAW68930 EAW68931 Q9BY76 AB056477 BAB40692 AF153606 AAD41088 AF169312 AAF62868 AF202636 AAG22490 AK222489 BAD96209 AK222524 BAD96244 AK303269 BAG64351 AW954426 AY358275 AAQ88642 BC023647 AAH23647 BG424907 BP397348 HQ447738 ADQ32223 XM_005272484 XP_005272541 XM_005272485 XP_005272542 NM_001039667 NP_001034756 NM_139314 NP_647475 NR_104213 NM_016109
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:12015030}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F2788 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 20 pg/ml Range 0.312-20 ng/ml

Human ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F4394 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.34 ng/ml Range 0.312-20 ng/ml

Mouse ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F6608 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Human ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F31 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 27.43 pg/ml Range 0.312-20 ng/ml

Rat ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F7726 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 0.312-20 ng/ml

Human ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F10823 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 0.312-20 ng/ml

Mouse ANGPTL4 ELISA Kit (Sandwich ELISA) - LS-F10824 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.312-20 ng/ml

Human Angiopoietin-like 4 DuoSet ELISA - DY3485 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 1.25 - 80 ng/mL

Human ANGPTL2 ELISA Kit - abx150658 from Abbexa Category ELISA Kit Sensitivity 0.135 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human ANGPTL4 ELISA Kit - abx150660 from Abbexa Category ELISA Kit Sensitivity 0.31 ng/ml Range 0.781 ng/ml - 50 ng/ml

Human ANGPTL4 ELISA Kit - abx056012 from Abbexa Category ELISA Kit

Angiopoietin-related protein 2, ANGPTL2, Human, ELISA Kit - E1919h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Angiopoietin-related protein 4 (ANGPTL4), Human, ELISA Kit - CSB-EL001712HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Angiopoietin-related protein 4, ANGPTL4, Human, ELISA Kit - E2085h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 0.156-10 ng/mL

Angiopoietin Like Protein 2, ANGPTL2, Human, ELISA Kit - E-EL-H0335 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.281 Range 0.469-30ng/mL

ANGPTL2, Human, ELISA Kit - 27745 from ARP American Research Products Category ELISA Kit Prices $750.00 Sizes 96 t Range 0.05 - 3.5 ng/mL

Angiopoietin Like Protein 4, ANGPTL4, Human, ELISA Kit - E-EL-H0337 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.938 Range 1.563-100ng/mL

ANGPTL4, Human, ELISA Kit - 27749 from ARP American Research Products Category ELISA Kit Prices $750.00 Sizes 96 t Range 23.44 � 1,500 pg/mL

Angiopoietin Like Protein 2, ANGPTL2, Mouse, ELISA Kit - E-EL-M0092 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Angiopoietin Like Protein 4, ANGPTL4, Mouse, ELISA Kit - E-EL-M0093 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Angiopoietin Like Protein 2, ANGPTL2, Rabbit, ELISA Kit - E-EL-RB0718 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Angiopoietin Like Protein 4, ANGPTL4, Rabbit, ELISA Kit - E-EL-RB0878 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Angiopoietin Like Protein 2, ANGPTL2, Chicken, ELISA Kit - E-EL-Ch1908 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Angiopoietin Like Protein 4, ANGPTL4, Chicken, ELISA Kit - E-EL-Ch1469 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Angiopoietin Like Protein 2, ANGPTL2, Porcine, ELISA Kit - E-EL-P0226 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

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