ANGPTL4
| Gene Symbol | ANGPTL4 |
|---|---|
| Entrez Gene | 51129 |
| Alt Symbol | ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158 |
| Species | Human |
| Gene Type | protein-coding |
| Description | angiopoietin-like 4 |
| Other Description | PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein |
| Swissprots | B4E089 Q9BY76 Q9Y5B3 Q53HQ6 D6W670 Q53HU1 A8MY84 Q6UXN0 Q9NZU4 Q9HBV4 F5H0I2 |
| Accessions | EAW68930 EAW68931 Q9BY76 AB056477 BAB40692 AF153606 AAD41088 AF169312 AAF62868 AF202636 AAG22490 AK222489 BAD96209 AK222524 BAD96244 AK303269 BAG64351 AW954426 AY358275 AAQ88642 BC023647 AAH23647 BG424907 BP397348 HQ447738 ADQ32223 XM_005272484 XP_005272541 XM_005272485 XP_005272542 NM_001039667 NP_001034756 NM_139314 NP_647475 NR_104213 NM_016109 |
| Function | Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}. |
| Tissue Specificity | Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:12015030}. |
| Top Pathways | PPAR signaling pathway |
Angptl4 CRISPR/Cas9 KO Plasmid (h) - sc-401369 from Santa Cruz Biotechnology
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Angptl4 HDR Plasmid (h) - sc-401369-HDR from Santa Cruz Biotechnology
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Angptl4 Double Nickase Plasmid (h) - sc-401369-NIC from Santa Cruz Biotechnology
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Angptl4 Double Nickase Plasmid (h2) - sc-401369-NIC-2 from Santa Cruz Biotechnology
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Angptl4 CRISPR Activation Plasmid (h) - sc-401369-ACT from Santa Cruz Biotechnology
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Angptl4 CRISPR Activation Plasmid (h2) - sc-401369-ACT-2 from Santa Cruz Biotechnology
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Angptl4 Lentiviral Activation Particles (h) - sc-401369-LAC from Santa Cruz Biotechnology
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Angptl4 Lentiviral Activation Particles (h2) - sc-401369-LAC-2 from Santa Cruz Biotechnology
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Angptl4 siRNA (h) - sc-44664 from Santa Cruz Biotechnology
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Angptl4 shRNA Plasmid (h) - sc-44664-SH from Santa Cruz Biotechnology
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Angptl4 shRNA (h) Lentiviral Particles - sc-44664-V from Santa Cruz Biotechnology
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Angiopoietin-like Protein 4/ANGPTL4 RNAi - H00051129-R01 from Novus Biologicals
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Angiopoietin-like Protein 4/ANGPTL4 RNAi - H00051129-R02 from Novus Biologicals
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Angiopoietin-like Protein 2/ANGPTL2 RNAi - H00023452-R01 from Novus Biologicals
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MISSION® esiRNA - EHU123661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2535 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2535 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05576 from Sigma-Aldrich
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ANGPTL4 siRNA (Human) - CRH9548 from Cohesion Biosciences
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ANGPTL4 - MBS8208012 from MyBioSource
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shRNA set against Human ANGPTL4 (NM_001039667.1) - SHH236294 from Creative biogene
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shRNA set against Human ANGPTL4(NM_139314.1) - SHG057953 from Creative biogene
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shRNA set against Human ANGPTL4(NM_001039667.1) - SHG057963 from Creative biogene
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shRNA set against Human ANGPTL4(NM_139314.1) - SHG058057 from Creative biogene
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shRNA set against Human ANGPTL4(NM_001039667.1) - SHG058065 from Creative biogene
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