ANGPTL4

Gene Symbol	ANGPTL4
Entrez Gene	51129
Alt Symbol	ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158
Species	Human
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
Swissprots	B4E089 Q9BY76 Q9Y5B3 Q53HQ6 D6W670 Q53HU1 A8MY84 Q6UXN0 Q9NZU4 Q9HBV4 F5H0I2
Accessions	EAW68930 EAW68931 Q9BY76 AB056477 BAB40692 AF153606 AAD41088 AF169312 AAF62868 AF202636 AAG22490 AK222489 BAD96209 AK222524 BAD96244 AK303269 BAG64351 AW954426 AY358275 AAQ88642 BC023647 AAH23647 BG424907 BP397348 HQ447738 ADQ32223 XM_005272484 XP_005272541 XM_005272485 XP_005272542 NM_001039667 NP_001034756 NM_139314 NP_647475 NR_104213 NM_016109
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:12015030}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Angiopoietin-like 4 protein fragment - ab108558 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source HEK 293 cells Species Human

Angiopoietin-like 4 peptide - ab123817 from Abcam Category Peptide Prices $176.00 Sizes 1 ml

Angiopoietin-like 4 peptide - ab4936 from Abcam Category Peptide Prices $176.00 Sizes 50 µg

Human Angiopoietin-like 4 full length protein - ab203544 from Abcam Category Protein Prices $346.00 Sizes 25 µg Source HEK 293 cells Species Human

Human Angiopoietin-like 4 full length protein - ab153331 from Abcam Category Protein Prices $402.00 Sizes 2 µg Source Wheat germ Species Human

Human Angiopoietin-like 4 full length protein - ab93216 from Abcam Category Protein Prices $454.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Angiopoietin-like 4 full length protein - ab109141 from Abcam Category Protein Source HEK 293 cells Species Human

Human Angiopoietin-like 4 peptide - ab74024 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Angiopoietin-like 4 protein fragment - ab153332 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Angiopoietin-like 4 protein fragment - ab191677 from Abcam Category Protein Prices $515.00 Sizes 100 µg Source HEK 293 cells Species Human

Human Angiopoietin-like 4 protein fragment - ab108582 from Abcam Category Protein Prices $300.00 Sizes 10 µg Source HEK 293 cells Species Human

Mouse Angiopoietin-like 4 protein fragment - ab108550 from Abcam Category Protein Source HEK 293 cells Species Mouse

Mouse Angiopoietin-like 4 protein fragment - ab109031 from Abcam Category Protein Source HEK 293 cells Species Mouse

ANGPTL4 Antibody Blocking Peptide - LS-E10004 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Angiopoietin-like Protein 4/ANGPTL4 Recombinant Protein - H00051129-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Angiopoietin-like Protein 4/ANGPTL4 Protein - H00051129-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Angiopoietin-like Protein 2/ANGPTL2 Recombinant Protein - H00023452-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Angiopoietin-like Protein 4/ANGPTL4 Blocking Peptide - NBP1-45565PEP from Novus Biologicals Category Protein Prices $95.00 Sizes 50 µg Species Human

ANGPTL4-Antibody-Center-Blocking-Peptide - BP9207c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Angiopoietin-like 4, CF - 4487-AN-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly26-Ser406 (Lys163Ala & Arg164Ala), with a C-terminal 6-His tag

Recombinant Human Angiopoietin-like 4 C-Terminal Frag, CF - 3485-AN-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Leu165-Ser406, with a C-terminal 6-His tag

Recombinant Human Angiopoietin-like 4 N-Terminal Frag, CF - 8249-AN-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

ANGPTL4 Human - Recombinant Human Angiopoietin-like Protein 4 (OPPA00514) - OPPA00514 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli Species Human

ANGPTL4 Protein (OPPA02122) - OPPA02122 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source HEK293 (Human Embryonic Kidney Cell Line)

Human ANGPTL2 protein - orb191201 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli Species Human

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