ANGPTL4

Gene Symbol	ANGPTL4
Entrez Gene	51129
Alt Symbol	ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158
Species	Human
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
Swissprots	B4E089 Q9BY76 Q9Y5B3 Q53HQ6 D6W670 Q53HU1 A8MY84 Q6UXN0 Q9NZU4 Q9HBV4 F5H0I2
Accessions	EAW68930 EAW68931 Q9BY76 AB056477 BAB40692 AF153606 AAD41088 AF169312 AAF62868 AF202636 AAG22490 AK222489 BAD96209 AK222524 BAD96244 AK303269 BAG64351 AW954426 AY358275 AAQ88642 BC023647 AAH23647 BG424907 BP397348 HQ447738 ADQ32223 XM_005272484 XP_005272541 XM_005272485 XP_005272542 NM_001039667 NP_001034756 NM_139314 NP_647475 NR_104213 NM_016109
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:12015030}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Angptl4 (A-2) - sc-373761 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Angptl4 (C-7) - sc-373762 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Angptl4 (H-200) - sc-66806 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Angptl4 (L-17) - sc-32186 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Angptl4 (N-15) - sc-34113 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Angiopoietin-like 4 antibody - ab196746 from Abcam Prices $384.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Angiopoietin-like 4 antibody - ab115798 from Abcam Prices $378.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Angiopoietin-like 4 antibody - ab47046 from Abcam Prices $359.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Angiopoietin-like 4 antibody - ab95194 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Angiopoietin-like 4 antibody [11F6C4] - ab138526 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 11F6C4

Anti-Angiopoietin-like 4 antibody [EPR7859(2)] - ab134957 from Abcam

Human ANGPTL2 full length protein - ab202193 from Abcam Prices $571.00 Sizes 50 µg

Anti-ANGPTL4 Antibody (aa80-94) - LS-C6815 from LifeSpan Bioscience Prices $495.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody - LS-C48470 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (N-Terminus) - LS-C46985 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody - LS-C126776 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody - LS-C129036 from LifeSpan Bioscience Prices $445.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-ANGPTL4 Antibody (aa81-94) - LS-C66040 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (Internal) - LS-C210036 from LifeSpan Bioscience Prices $295.00 Sizes 250 µl Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (aa182-394) - LS-C292825 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (Internal, clone EPR7859(2)) - LS-C154731 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7859(2)

Anti-ANGPTL4 Antibody (aa182-388, Biotin) - LS-C298324 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (clone 1A12) - LS-C139056 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A12

Anti-ANGPTL4 Antibody (aa182-394, Biotin) - LS-C298329 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ANGPTL4 Antibody (aa182-394) - LS-C292365 from LifeSpan Bioscience Prices $425.00 Sizes 200 µg Host Mouse Clonality Monoclonal

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