ANGPTL4

Gene Symbol	ANGPTL4
Entrez Gene	51129
Alt Symbol	ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, TGQTL, UNQ171, pp1158
Species	Human
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	PPARG angiopoietin related protein|angiopoietin-related protein 4|fasting-induced adipose factor|hepatic angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein
Swissprots	B4E089 Q9BY76 Q9Y5B3 Q53HQ6 D6W670 Q53HU1 A8MY84 Q6UXN0 Q9NZU4 Q9HBV4 F5H0I2
Accessions	EAW68930 EAW68931 Q9BY76 AB056477 BAB40692 AF153606 AAD41088 AF169312 AAF62868 AF202636 AAG22490 AK222489 BAD96209 AK222524 BAD96244 AK303269 BAG64351 AW954426 AY358275 AAQ88642 BC023647 AAH23647 BG424907 BP397348 HQ447738 ADQ32223 XM_005272484 XP_005272541 XM_005272485 XP_005272542 NM_001039667 NP_001034756 NM_139314 NP_647475 NR_104213 NM_016109
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:10698685}. Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4 (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney. {ECO:0000269|PubMed:10698685, ECO:0000269|PubMed:12015030}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ANGPTL4 / FIAF Lysate(Denatured) - H00051129-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ANGPTL4 overexpression lysate - LY403389 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ANGPTL4 overexpression lysate - LY422106 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ANGPTL4 293 Cell Lysate - 402936 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Angiopoietin-like Protein 4/ANGPTL4 Overexpression Lysate (Denatured) - H00051129-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Angiopoietin-like Protein 4/ANGPTL4 Overexpression Lysate (Native) - NBL1-07527 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ANGPTL4 Over-expression Lysate Product - GWB-55D85F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human ANGPTL4 HEK293 Cell Lysate (WB positive control) - 10563-H07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human ANGPTL4 HEK293 Cell Lysate (WB positive control) - 10563-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human ANGPTL4 Human Cells Transfected Lysate (positive control) (denatured) - orb174572 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Angiopoietin-like Protein 4/ANGPTL4 Overexpression Lysate (Denatured) - H00051129-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human ANGPTL4 Human Cells Transfected Lysate (positive control) (denatured) - orb174172 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human ANGPTL4 Knockdown Stable Cell Line - CSC-DC000597 from Creative biogene Category Cell Line Species Human

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