Gene Symbol | AEBP1 |
---|---|
Entrez Gene | 165 |
Alt Symbol | ACLP |
Species | Human |
Gene Type | protein-coding |
Description | AE binding protein 1 |
Other Description | adipocyte enhancer-binding protein 1|aortic carboxypeptidase-like protein |
Swissprots | Q59ER7 Q14113 Q7KZ79 Q6ZSC7 Q8IUX7 |
Accessions | EAL23768 EAW61119 Q8IUX7 AB209744 BAD92981 AF053944 AAC25585 AK090931 BAG52248 AK127541 BAC87026 AK296001 BAG58775 BC038588 AAH38588 BM672693 D86479 BAA13094 DB213495 XM_011515162 XP_011513464 NM_001129 NP_001120 |
Function | May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250}. |
Subcellular Location | Isoform 1: Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in osteoblast and visceral fat. {ECO:0000269|PubMed:8920928}. |