Gene Symbol | AEBP1 |
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Entrez Gene | 165 |
Alt Symbol | ACLP |
Species | Human |
Gene Type | protein-coding |
Description | AE binding protein 1 |
Other Description | adipocyte enhancer-binding protein 1|aortic carboxypeptidase-like protein |
Swissprots | Q59ER7 Q14113 Q7KZ79 Q6ZSC7 Q8IUX7 |
Accessions | EAL23768 EAW61119 Q8IUX7 AB209744 BAD92981 AF053944 AAC25585 AK090931 BAG52248 AK127541 BAC87026 AK296001 BAG58775 BC038588 AAH38588 BM672693 D86479 BAA13094 DB213495 XM_011515162 XP_011513464 NM_001129 NP_001120 |
Function | May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000250}. |
Subcellular Location | Isoform 1: Secreted {ECO:0000250}. |
Tissue Specificity | Expressed in osteoblast and visceral fat. {ECO:0000269|PubMed:8920928}. |
AEBP1 CRISPR/Cas9 KO Plasmid (h) - sc-403540 from Santa Cruz Biotechnology
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AEBP1 HDR Plasmid (h) - sc-403540-HDR from Santa Cruz Biotechnology
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AEBP1 Double Nickase Plasmid (h) - sc-403540-NIC from Santa Cruz Biotechnology
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AEBP1 Double Nickase Plasmid (h2) - sc-403540-NIC-2 from Santa Cruz Biotechnology
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AEBP1 CRISPR Activation Plasmid (h) - sc-403540-ACT from Santa Cruz Biotechnology
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AEBP1 CRISPR Activation Plasmid (h2) - sc-403540-ACT-2 from Santa Cruz Biotechnology
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AEBP1 Lentiviral Activation Particles (h) - sc-403540-LAC from Santa Cruz Biotechnology
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AEBP1 Lentiviral Activation Particles (h2) - sc-403540-LAC-2 from Santa Cruz Biotechnology
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AEBP1 siRNA (h) - sc-40327 from Santa Cruz Biotechnology
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AEBP1 shRNA Plasmid (h) - sc-40327-SH from Santa Cruz Biotechnology
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AEBP1 shRNA (h) Lentiviral Particles - sc-40327-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU043741 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2908 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2908 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01703 from Sigma-Aldrich
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AEBP1 siRNA (Human) - CRH0119 from Cohesion Biosciences
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AE Binding Protein 1/ACLP RNAi - H00000165-R01 from Novus Biologicals
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AEBP1 - MBS8231511 from MyBioSource
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AEBP1 CRISPR/Cas9 KO Plasmid (h2) - sc-403540-KO-2 from Santa Cruz Biotechnology
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AEBP1 HDR Plasmid (h2) - sc-403540-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human AEBP1 (NM_001129.3) - SHH232848 from Creative biogene
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shRNA set against Human AEBP1(NM_001129.3) - SHG044497 from Creative biogene
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Human AEBP1 siRNA - orb260621 from Biorbyt
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AEBP1 shRNA Plasmid (Human) - CHH0119 from Cohesion Biosciences
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AEBP1 miRNA 3'UTR clone - MiUTR1H-00223 from Creative biogene
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