SMAD7

Gene Symbol	SMAD7
Entrez Gene	4092
Alt Symbol	CRCS3, MADH7, MADH8
Species	Human
Gene Type	protein-coding
Description	SMAD family member 7
Other Description	MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7
Swissprots	Q6DK23 B7Z773 K7EQ10 O14740 O15105
Accessions	AAL68977 EAW62931 O15105 AF010193 AAB81246 AF015261 AAB81354 AK131394 BAG54770 AK301535 BAH13509 BC074818 AAH74818 BC074819 AAH74819 BP363832 DA882147 NM_001190821 NP_001177750 NM_001190822 NP_001177751 NM_001190823 NP_001177752 NM_005904 NP_005895
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
Tissue Specificity	Ubiquitous with higher expression in the lung and vascular endothelium.
Top Pathways	TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rat SMAD7 ELISA Kit (Sandwich ELISA) - LS-F4517 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.054 ng/ml Range 0.156-10 ng/ml

Human SMAD7 ELISA Kit (Sandwich ELISA) - LS-F4518 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse SMAD7 ELISA Kit (Sandwich ELISA) - LS-F12618 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.156-10 ng/ml

Human SMAD7 ELISA Kit (Sandwich ELISA) - LS-F12617 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 0.156-10 ng/ml

Mothers Against Decapentaplegic Homolog 7, Human, ELISA Kit - E01S0270 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/mL,

Mothers against decapentaplegic homolog 7, Smad7, Human, ELISA Kit - CSB-E09228h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.039 ng/ml Range 0.156 ng/ml-10 ng/ml

Mothers against decapentaplegic homolog 7, SMAD7, Human, ELISA Kit - E0648h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Human, ELISA Kit - E-EL-H0934 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Mothers Against Decapentaplegic Homolog 7, Smad7, Mouse, ELISA Kit - E-EL-M1066 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Mothers Against Decapentaplegic Homolog 7, Smad7, Rat, ELISA Kit - E-EL-R0061 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Rabbit, ELISA Kit - E-EL-RB1714 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Chicken, ELISA Kit - E-EL-Ch0233 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Porcine, ELISA Kit - E-EL-P0202 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Guinea Pig, ELISA Kit - E-EL-GP0610 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7, Smad7/MADH7, Monkey, ELISA Kit - E-EL-MK1361 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human Smad7 ELISA Kit - HS0277 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine Smad7 ELISA Kit - AS0277 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mothers Against Decapentaplegic Homolog 7, ELISA Kit - MBS046319 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mothers Against Decapentaplegic Homolog 7, ELISA Kit - MBS023792 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit - MBS9307516 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mothers Against Decapentaplegic Homolog 7 (Smad7), ELISA Kit - MBS9307863 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) - SEA648Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Mothers Against Decapentaplegic Homolog 7 (Smad7) - SEA648Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.057ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Smad7/MADH7(Mothers Against Decapentaplegic Homolog 7) ELISA Kit - E-EL-H0934 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human Smad7/MADH7 (Mothers Against Decapentaplegic Homolog 7) CLIA Kit - E-CL-H0638 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

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