| Gene Symbol |
SMAD7
|
| Entrez Gene |
4092
|
| Alt Symbol |
CRCS3, MADH7, MADH8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMAD family member 7
|
| Other Description |
MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7
|
| Swissprots |
Q6DK23 B7Z773 K7EQ10 O14740 O15105
|
| Accessions |
AAL68977 EAW62931 O15105 AF010193 AAB81246 AF015261 AAB81354 AK131394 BAG54770 AK301535 BAH13509 BC074818 AAH74818 BC074819 AAH74819 BP363832 DA882147 NM_001190821 NP_001177750 NM_001190822 NP_001177751 NM_001190823 NP_001177752 NM_005904 NP_005895
|
| Function |
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
|
| Tissue Specificity |
Ubiquitous with higher expression in the lung and vascular endothelium.
|
| Top Pathways |
TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway
|
![Western Blot: SMAD7 Overexpression Lysate (Adult Normal) [NBP2-07689] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMAD7.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/790_SMAD7%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07689-img0001.jpg)