SMAD7
| Gene Symbol | SMAD7 |
|---|---|
| Entrez Gene | 4092 |
| Alt Symbol | CRCS3, MADH7, MADH8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | SMAD family member 7 |
| Other Description | MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7 |
| Swissprots | Q6DK23 B7Z773 K7EQ10 O14740 O15105 |
| Accessions | AAL68977 EAW62931 O15105 AF010193 AAB81246 AF015261 AAB81354 AK131394 BAG54770 AK301535 BAH13509 BC074818 AAH74818 BC074819 AAH74819 BP363832 DA882147 NM_001190821 NP_001177750 NM_001190822 NP_001177751 NM_001190823 NP_001177752 NM_005904 NP_005895 |
| Function | Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta. |
| Tissue Specificity | Ubiquitous with higher expression in the lung and vascular endothelium. |
| Top Pathways | TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway |
Smad7 CRISPR/Cas9 KO Plasmid (h) - sc-400251 from Santa Cruz Biotechnology
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Smad7 HDR Plasmid (h) - sc-400251-HDR from Santa Cruz Biotechnology
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Smad7 Double Nickase Plasmid (h) - sc-400251-NIC from Santa Cruz Biotechnology
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Smad7 Double Nickase Plasmid (h2) - sc-400251-NIC-2 from Santa Cruz Biotechnology
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Smad7 CRISPR Activation Plasmid (h) - sc-400251-ACT from Santa Cruz Biotechnology
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Smad7 CRISPR Activation Plasmid (h2) - sc-400251-ACT-2 from Santa Cruz Biotechnology
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Smad7 Lentiviral Activation Particles (h) - sc-400251-LAC from Santa Cruz Biotechnology
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Smad7 Lentiviral Activation Particles (h2) - sc-400251-LAC-2 from Santa Cruz Biotechnology
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Smad7 siRNA (h) - sc-36508 from Santa Cruz Biotechnology
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Smad7 shRNA Plasmid (h) - sc-36508-SH from Santa Cruz Biotechnology
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Smad7 shRNA (h) Lentiviral Particles - sc-36508-V from Santa Cruz Biotechnology
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Smad7 RNAi - H00004092-R01 from Novus Biologicals
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MISSION® esiRNA - EHU037321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19755 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19755 from Sigma-Aldrich
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SMAD7 siRNA (Human) - CRH2775 from Cohesion Biosciences
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SMAD7 - MBS8218113 from MyBioSource
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shRNA set against Human SMAD7 (NM_005904.3) - SHH413020 from Creative biogene
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Smad7 CRISPR/Cas9 KO Plasmid (h2) - sc-400251-KO-2 from Santa Cruz Biotechnology
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Smad7 HDR Plasmid (h2) - sc-400251-HDR-2 from Santa Cruz Biotechnology
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Human SMAD7 siRNA - orb263277 from Biorbyt
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SMAD7 shRNA Plasmid (Human) - CHH2775 from Cohesion Biosciences
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SMAD7 miRNA 3'UTR clone - MiUTR3H-05425 from Creative biogene
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