SMAD7

Gene Symbol	SMAD7
Entrez Gene	4092
Alt Symbol	CRCS3, MADH7, MADH8
Species	Human
Gene Type	protein-coding
Description	SMAD family member 7
Other Description	MAD (mothers against decapentaplegic, Drosophila) homolog 7|MAD homolog 8|Mothers against decapentaplegic, drosophila, homolog of, 7|SMAD, mothers against DPP homolog 7|hSMAD7|mothers against DPP homolog 8|mothers against decapentaplegic homolog 7
Swissprots	Q6DK23 B7Z773 K7EQ10 O14740 O15105
Accessions	AAL68977 EAW62931 O15105 AF010193 AAB81246 AF015261 AAB81354 AK131394 BAG54770 AK301535 BAH13509 BC074818 AAH74818 BC074819 AAH74819 BP363832 DA882147 NM_001190821 NP_001177750 NM_001190822 NP_001177751 NM_001190823 NP_001177752 NM_005904 NP_005895
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A- PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 or induces translocation from the nucleus to the cytoplasm. TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta.
Tissue Specificity	Ubiquitous with higher expression in the lung and vascular endothelium.
Top Pathways	TGF-beta signaling pathway, Endocytosis, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MADH7 peptide - ab24477 from Abcam Category Peptide

Human MADH7 peptide - ab103933 from Abcam Category Peptide

Human MADH7 protein fragment - ab114358 from Abcam Category Protein Source Wheat germ Species Human

SMAD7 Antibody Blocking Peptide - LS-E8438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SMAD7 Antibody Blocking Peptide - LS-E11185 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Smad7 Protein - H00004092-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Smad7-Antibody-Center-Blocking-Peptide - BP6753c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Smad7-Antibody-C-term-Blocking-Peptide - BP6753b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SMAD 7 Blocking Peptide - 33R-10867 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

SMAD7 Blocking Peptide - abx062906 from Abbexa Category Peptide Species Human, Mouse, Rat, Pig

SMAD7 - H00004092-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMAD7 - H00004092-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMAD7 fusion protein - Ag13688 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SMAD7 - SMAD7-29105TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) - RPA648Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) - RPA648Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Mothers Against Decapentaplegic Homolog 7 (Smad7) - RPA648Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Smad7 - 23-039 from EMD Millipore Prices $473.00 Sizes 10 µg

Smad7 - 23-039-K from EMD Millipore Species Human

Smad7 - 23-039M from EMD Millipore Prices $2,709.00 Sizes bulk

SMAD7 Blocking Peptide - CBP1712 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Pig

Recombinant Human Mothers against decapentaplegic homolog 7(SMAD7) - CSB-YP021793HU CSB-EP021793HU CSB-BP021793HU CSB-MP021793HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Smad7 Blocking Peptide - 3670BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

SMAD7 Protein - abx163623 from Abbexa Category Protein Species Mouse, Rat

SMAD7 Protein - abx163007 from Abbexa Category Protein Species Human

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