| Gene Symbol |
TFAP2A
|
| Entrez Gene |
7020
|
| Alt Symbol |
AP-2, AP-2alpha, AP2TF, BOFS, TFAP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
|
| Other Description |
AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha
|
| Swissprots |
Q13777 P05549 Q5TAV5 Q8N1C6
|
| Accessions |
AAK54356 CAA64522 CAB59735 EAW55248 EAW55249 EAW55250 EAW55251 P05549 AK296737 BAH12422 BC017754 AAH17754 BC071713 CB990517 DQ891099 ABM82025 DQ894281 ABM85207 FJ794945 ACN93799 M36711 AAA35539 M61156 AAA02487 X52611 CAA36842 XM_006715175 XP_006715238 XM_011514833 XP_011513135 NM_001032280 NP_001027451 NM_001042425 NP_001035890 NM_003220 NP_003211
|
| Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12586840}.
|
![Western Blot: AP2 alpha Overexpression Lysate (Adult Normal) [NBP2-11607] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AP2 alpha.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2590_AP2%2520alpha%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11607-img0001.jpg)