Gene Symbol | TFAP2A |
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Entrez Gene | 7020 |
Alt Symbol | AP-2, AP-2alpha, AP2TF, BOFS, TFAP2 |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Other Description | AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha |
Swissprots | Q13777 P05549 Q5TAV5 Q8N1C6 |
Accessions | AAK54356 CAA64522 CAB59735 EAW55248 EAW55249 EAW55250 EAW55251 P05549 AK296737 BAH12422 BC017754 AAH17754 BC071713 CB990517 DQ891099 ABM82025 DQ894281 ABM85207 FJ794945 ACN93799 M36711 AAA35539 M61156 AAA02487 X52611 CAA36842 XM_006715175 XP_006715238 XM_011514833 XP_011513135 NM_001032280 NP_001027451 NM_001042425 NP_001035890 NM_003220 NP_003211 |
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12586840}. |
Human AP2 alpha full length protein - ab132085 from Abcam
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Human AP2 alpha protein fragment - ab114726 from Abcam
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TFAP2A / AP-2 Antibody Blocking Peptide - LS-E10855 from LifeSpan Bioscience
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TFAP2A / AP-2 Antibody Blocking Peptide - LS-E6781 from LifeSpan Bioscience
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TFAP2A / AP-2 Antibody Blocking Peptide - LS-E26412 from LifeSpan Bioscience
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AP2 alpha Peptide - NBP1-96941 from Novus Biologicals
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AP2 alpha Recombinant Protein - H00007020-P01 from Novus Biologicals
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Recombinant Human AP2 alpha Protein - H00007020-Q01 from Novus Biologicals
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AP2 alpha Peptide - P0766 from Novus Biologicals
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TFAP2A-Antibody-C-term-Blocking-Peptide - BP1976b from Abgent, a WuXi AppTec company
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TFAP2A peptide - orb218009 from Biorbyt
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Tfap2a Immunizing peptide - orb50431 from Biorbyt
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TFAP2A / AP-2 alpha - H00007020-P01-10 from Acris Antibodies
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TFAP2A / AP-2 alpha - H00007020-P01-25 from Acris Antibodies
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TFAP2A / AP-2 alpha - H00007020-Q01-10 from Acris Antibodies
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TFAP2A / AP-2 alpha - H00007020-Q01-25 from Acris Antibodies
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TFAP2A,AP-2 fusion protein - Ag4112 from Proteintech Group
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Recombinant AP-2α protein - 31331 from ActiveMotif
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Recombinant Human TFAP2A - TFAP2A-27355TH from Creative Biomart
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Recombinant Human TFAP2A - TFAP2A-144H from Creative Biomart
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AP2 alpha/beta Blocking Peptide - CBP2146 from Cohesion Biosciences
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TFAP2A (K431) Peptide - BS1015P from Bioworld Technology
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Recombinant Human Transcription factor AP-2-alpha(TFAP2A) - CSB-YP023414HU CSB-EP023414HU CSB-BP023414HU CSB-MP023414HU from Cusabio
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TFAP2A / AP-2 alpha (transcript variant 2) - TP304603 from Acris Antibodies
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AP2 alpha Recombinant Protein Antigen - NBP2-38809PEP from Novus Biologicals
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