Gene Symbol | TFAP2A |
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Entrez Gene | 7020 |
Alt Symbol | AP-2, AP-2alpha, AP2TF, BOFS, TFAP2 |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
Other Description | AP-2 transcription factor|AP2-alpha|activating enhancer-binding protein 2-alpha|activator protein 2|transcription factor AP-2-alpha |
Swissprots | Q13777 P05549 Q5TAV5 Q8N1C6 |
Accessions | AAK54356 CAA64522 CAB59735 EAW55248 EAW55249 EAW55250 EAW55251 P05549 AK296737 BAH12422 BC017754 AAH17754 BC071713 CB990517 DQ891099 ABM82025 DQ894281 ABM85207 FJ794945 ACN93799 M36711 AAA35539 M61156 AAA02487 X52611 CAA36842 XM_006715175 XP_006715238 XM_011514833 XP_011513135 NM_001032280 NP_001027451 NM_001042425 NP_001035890 NM_003220 NP_003211 |
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:11694877, ECO:0000269|PubMed:12586840}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12586840}. |
Human-TFAP2A-cDNA-Clone - DC04573 from Abgent, a WuXi AppTec company
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TFAP2A - MBS1277024 from MyBioSource
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Human TFAP2A cDNA clone(NM_001032280.2) - CDFH019472 from Creative Biomart
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Human TFAP2A cDNA clone(NM_001042425.1) - CDFH019473 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001032280.2) - CDCL178273 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001032280.2) - CDCR342948 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001032280.2) - CDCR342949 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001042425.1) - CDCR344479 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001042425.1) - CDCR344480 from Creative Biomart
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human TFAP2A ORF clone - CDCH090400 from Creative Biomart
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human TFAP2A ORF clone - CDCH090401 from Creative Biomart
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human TFAP2A ORF clone - CDCH090402 from Creative Biomart
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human TFAP2A ORF clone - CDCH090403 from Creative Biomart
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human TFAP2A ORF clone - CDCH090404 from Creative Biomart
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human TFAP2A ORF clone - CDCH090405 from Creative Biomart
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Human TFAP2A ORF Clone(NM_001032280.2) - CDCR342948 from Creative biogene
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human TFAP2A ORF clone (NM_001042425.1) - CDCH090400 from Creative biogene
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human TFAP2A ORF clone (NM_003220.2) - CDCH090402 from Creative biogene
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Human TFAP2A ORF Clone (BC017754) - CDCS406781 from Creative biogene
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Human TFAP2A cDNA Clone(NM_001032280.2) - CDFH019472 from Creative biogene
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Human TFAP2A cDNA Clone(NM_001042425.1) - CDFH019473 from Creative biogene
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