TDO2

Gene Symbol TDO2
Entrez Gene 6999
Alt Symbol TDO, TO, TPH2, TRPO
Species Human
Gene Type protein-coding
Description tryptophan 2,3-dioxygenase
Other Description TDO|TO|TRPO|tryptamin 2,3-dioxygenase|tryptophan oxygenase|tryptophan pyrrolase|tryptophanase
Swissprots A8K053 P48775
Accessions EAX04884 EAX04885 EAX04886 P48775 AA705255 AK289418 BAF82107 AK307741 BC005355 AAH05355 BG616664 BX647341 EU831460 ACE87147 EU831547 ACE86466 HQ447298 ADQ31785 U32989 AAB08514 NM_005651 NP_005642
Function Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). {ECO:0000250}.
Top Pathways Tryptophan metabolism

TDO2 (E-14) - sc-104696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TDO2 (E-14): sc-104696. Western blot analysis of TDO2 expression in MDA-MB-435S whole cell lysate.

TDO2 (G-18) - sc-104697 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TDO2 antibody - ab76859 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TDO2 antibody (ab76859) at 1/500 dilutionLane 1 : TDO2 transfected 293T cells lysateLane 2 : Non transfected 293T cells lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-TDO2 antibody - ab123403 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TDO2 antibody (ab123403) at 1/100 dilution + MDA-MB453 cell line lysate at 35 µg

Anti-TDO2 antibody - ab84926 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TDO2 antibody (ab84926) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal heart lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TDO2 antibody [1D1] - ab128532 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
Overlay histogram showing HepG2 cells stained with ab128532 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab128532, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-TDO2 Antibody (aa71-120) - LS-C111058 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TDO2 antibody LS-C111058 Western blot of Fetal Small Intestine lysate.

Anti-TDO2 Antibody (aa1-30, APC) - LS-C271229 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (aa1-30, AP) - LS-C271228 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (aa1-30, Biotin) - LS-C271230 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (aa1-30, FITC) - LS-C271231 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (aa1-30, Azide-free, HRP) - LS-C271232 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (clone 1B1) - LS-C173912 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.

Anti-TDO2 Antibody (aa1-30, PE) - LS-C271233 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (aa1-30) - LS-C330219 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TDO2 Antibody (clone 1C8) - LS-C198320 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C8
Detection limit for recombinant GST tagged TDO2 is approximately 10 ng/ml as a capture antibody.

Anti-TDO2 Antibody (aa1-30) - LS-C161783 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TDO2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The TDO2 antibody detected the TDO2 protein (arrow).

Anti-TDO2 Antibody - LS-C334932 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using TDO2 antibody.

Anti-TDO2 Antibody (clone 2A4) - LS-C174023 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A4
IHC of paraffin-embedded Human pancreas tissue using anti-TDO2 mouse monoclonal antibody.

Anti-TDO2 Antibody (clone 1D1) - LS-C337711 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.

Anti-TDO2 Antibody - LS-C345039 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis using anti-TDO (human), pAb at 1:2000 dilution. 1: Human TDO (His-tagged). 2: Human IDO (His-tagged). 3: Mouse IDO (His-tagged). 4: SH-sy5y cell lysate. 5: Unrelated protein (His-tagged) (negative control).

Anti-TDO2 Antibody (clone 4G2) IHC-plus™ - LS-B10427 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 4G2
Anti-TDO / TPH2 / TDO2 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TDO2 Antibody (N-Terminus) IHC-plus™ - LS-B5791 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5791 concentration 5 ug/ml.

TDO2 Antibody - NBP1-54877 from Novus Biologicals

Prices $369.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

TDO2 Antibody (1D1) - NBP2-02002 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D1
Western Blot: TDO2 Antibody (1D1) [NBP2-02002] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
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