SIT1

Gene Symbol	SIT1
Entrez Gene	27240
Alt Symbol	SIT, SIT-R
Species	Human
Gene Type	protein-coding
Description	signaling threshold regulating transmembrane adaptor 1
Other Description	SHP-2 interacting transmembrane adaptor protein\|SHP2 interacting transmembrane adaptor\|SHP2-interacting transmembrane adapter protein\|SHP2-interacting transmembrane adaptor protein\|gp30/40\|signaling threshold-regulating transmembrane adapter 1\|suppression inducing transmembrane adaptor 1\|suppression-inducing transmembrane adapter 1
Swissprots	Q9Y3P8 B2RBP9
Accessions	CAC81313 EAW58370 Q9Y3P8 AA310964 AA746595 AJ010059 CAB41504 AK314758 BAG37296 BC102029 AAI02030 BC104491 AAI04492 BC107484 AAI07485 BM919490 JQ924063 AFK32776 NM_014450 NP_055265
Function	Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269\|PubMed:10209036}.
Subcellular Location	Cell membrane {ECO:0000269\|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269\|PubMed:10209036}.
Tissue Specificity	Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. {ECO:0000269\|PubMed:10209036, ECO:0000269\|PubMed:16160011}.

SIT (F-9) - sc-271933 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

SIT (F-9): sc-271933. Western blot analysis of SIT expression in Jurkat whole cell lysate.

SIT (G-8) - sc-271202 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

SIT (G-8): sc-271202. Western blot analysis of SIT expression in Jurkat whole cell lysate.

SIT (FL-196) - sc-33811 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

SIT (C-20) - sc-15489 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SIT (C-20): sc-15489. Western blot analysis of SIT expression in HuT 78 (A), BYDP (B) and CTLL-2 (C) whole cell lysates.

SIT (N-20) - sc-15603 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SIT (N-20): sc-15603. Western blot analysis of SIT expression in HuT 78 (A), WEHI-231 (B) and H9 (C) whole cell lysates.

Anti-SIT antibody - ab130342 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT antibody (ab130342) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-SIT antibody [SIT-01] - ab9528 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

IHC image of ab9528 staining in human normal tonsil formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab9528, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-SIT antibody [SIT-01] (Phycoerythrin) - ab36418 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

Anti-SIT1 Antibody (Intracellular, clone SIT-01) - LS-C45988 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

Anti-SIT1 Antibody (Intracellular, clone SIT-01, PE) - LS-C46498 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

Anti-SIT1 Antibody (Intracellular) - LS-C91413 from LifeSpan Bioscience

Prices	$530.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-SIT1 Antibody (clone SIT-01) - LS-C124531 from LifeSpan Bioscience

Prices	$515.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

Anti-SIT1 Antibody (clone SIT-01) - LS-C202266 from LifeSpan Bioscience

Prices	$285.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SIT-01

Anti-SIT1 Antibody (aa62-74) - LS-C112944 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, APC) - LS-C269477 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, AP) - LS-C269473 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, Biotin) - LS-C269478 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, Azide-free, HRP) - LS-C269480 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, FITC) - LS-C269479 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189, PE) - LS-C269481 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa2-175, Biotin) - LS-C297651 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa2-175, FITC) - LS-C304020 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa160-189) - LS-C325126 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa2-175) - LS-C296435 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SIT1 Antibody (aa161-189) - LS-C161106 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SIT1 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The SIT1 antibody detected the SIT1 protein (arrow).

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