| Gene Symbol |
SIT1
|
| Entrez Gene |
27240
|
| Alt Symbol |
SIT, SIT-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
signaling threshold regulating transmembrane adaptor 1
|
| Other Description |
SHP-2 interacting transmembrane adaptor protein|SHP2 interacting transmembrane adaptor|SHP2-interacting transmembrane adapter protein|SHP2-interacting transmembrane adaptor protein|gp30/40|signaling threshold-regulating transmembrane adapter 1|suppression inducing transmembrane adaptor 1|suppression-inducing transmembrane adapter 1
|
| Swissprots |
Q9Y3P8 B2RBP9
|
| Accessions |
CAC81313 EAW58370 Q9Y3P8 AA310964 AA746595 AJ010059 CAB41504 AK314758 BAG37296 BC102029 AAI02030 BC104491 AAI04492 BC107484 AAI07485 BM919490 JQ924063 AFK32776 NM_014450 NP_055265
|
| Function |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells. {ECO:0000269|PubMed:10209036}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:10209036}; Single-pass type I membrane protein {ECO:0000269|PubMed:10209036}.
|
| Tissue Specificity |
Specifically expressed in T- and B-cells. Present in plasma cells but not in germinal center B-cells (at protein level). Expressed in T- and B-cell lymphoma. {ECO:0000269|PubMed:10209036, ECO:0000269|PubMed:16160011}.
|