GGH

Gene Symbol GGH
Entrez Gene 8836
Alt Symbol GH
Species Human
Gene Type protein-coding
Description gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Other Description gamma-Glu-X carboxypeptidase|gamma-glutamyl hydrolase
Swissprots Q92820
Accessions AAF03360 EAW86862 Q92820 AK290450 BAF83139 AK301094 BAG62694 BC025025 AAH25025 JF432643 ADZ15860 U55206 AAC05579 XM_011517623 XP_011515925 NM_003878 NP_003869
Function Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Subcellular Location Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Folate biosynthesis

GGH (S-15) - sc-69276 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GGH (T-20) - sc-69277 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Glutamyl hydrolase gamma antibody - ab110074 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamyl hydrolase gamma antibody (ab110074) at 1/500 dilutionLane 1 : Extracts from RAW264.7Lane 2 : Extracts from RAW264.7 with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-Glutamyl hydrolase gamma antibody - ab125473 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutamyl hydrolase gamma antibody (ab125473) at 1 µg/ml + Human Fetal Kidney Lysate at 10 µg

Anti-Glutamyl hydrolase gamma antibody - ab196244 from Abcam

Prices $376.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamyl hydrolase gamma antibody (ab196244) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : Human fetal kidney lysate

Anti-Glutamyl hydrolase gamma antibody [EPR8014] - ab138495 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8014
All lanes : Anti-Glutamyl hydrolase gamma antibody [EPR8014] (ab138495) at 1/1000 dilutionLane 1 : MCF7 cell lysateLane 2 : HepG2 cell lysateLane 3 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Glutamyl hydrolase gamma antibody - Azide free - ab37802 from Abcam

Prices $378.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-Glutamyl hydrolase gamma antibody - Azide free (ab37802) at 1/2000 dilution + E. coli derived fusion proteinSecondaryHRP conjugated Goat anti IgY at 1/1000 dilution

Anti-Glutamyl hydrolase gamma antibody - C-terminal - ab170729 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Flow cytometric analysis of NCI-H460 cells labeling Glutamyl hydrolase gamma with ab170729 at 1/10 dilution (right histogram) compared to negative control cells (left histogram). FITC-conjugated donkey-anti-rabbit secondary antibodies were used.

Anti-Glutamyl hydrolase gamma antibody - N-terminal - ab170315 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutamyl hydrolase gamma antibody - N-terminal (ab170315) at 1/100 dilution + HL-60 cell line lysate at 35 µg

Anti-GH / HGH Antibody (aa280-295) - LS-C147893 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (Internal, clone 15B) - LS-C191747 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Clone 15B

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, AP) - LS-C214678 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, APC) - LS-C214679 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, Biotin) - LS-C214680 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, Azide-free, HRP) - LS-C214682 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, FITC) - LS-C214681 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa229-256, PE) - LS-C214683 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa251-300) - LS-C119991 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from RAW264.7 cells, using GGH Antibody. The lane on the right is treated with the synthesized peptide.

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, AP) - LS-C214684 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, APC) - LS-C214685 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (Lys287) - LS-C177839 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of GGH (K287) pAb in extracts from RAW264.7 cells.

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, Biotin) - LS-C214686 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, PE) - LS-C214689 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, FITC) - LS-C214687 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGH / Gamma-Glutamyl Hydrolase Antibody (aa7-34, Azide-free, HRP) - LS-C214688 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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