GGH

Gene Symbol GGH
Entrez Gene 8836
Alt Symbol GH
Species Human
Gene Type protein-coding
Description gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
Other Description gamma-Glu-X carboxypeptidase|gamma-glutamyl hydrolase
Swissprots Q92820
Accessions AAF03360 EAW86862 Q92820 AK290450 BAF83139 AK301094 BAG62694 BC025025 AAH25025 JF432643 ADZ15860 U55206 AAC05579 XM_011517623 XP_011515925 NM_003878 NP_003869
Function Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
Subcellular Location Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Top Pathways Folate biosynthesis

GGH CRISPR/Cas9 KO Plasmid (h) - sc-409724 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH HDR Plasmid (h) - sc-409724-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH Double Nickase Plasmid (h) - sc-409724-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH Double Nickase Plasmid (h2) - sc-409724-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH CRISPR Activation Plasmid (h) - sc-409724-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH CRISPR Activation Plasmid (h2) - sc-409724-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH Lentiviral Activation Particles (h) - sc-409724-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH Lentiviral Activation Particles (h2) - sc-409724-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GGH siRNA (h) - sc-75127 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GGH shRNA Plasmid (h) - sc-75127-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GGH shRNA (h) Lentiviral Particles - sc-75127-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU023291 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9257 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9257 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GGH siRNA (Human) - CRH5832 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GGH - MBS8214764 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GGH (NM_003878.2) - SHH300794 from Creative biogene

Category siRNA
Species Reactivities Human

Human GGH siRNA - orb266334 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GGH shRNA Plasmid (Human) - CHH5832 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GGH miRNA 3'UTR clone - MiUTR3H-04169 from Creative biogene

Species Reactivities Human
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