| Gene Symbol |
GGH
|
| Entrez Gene |
8836
|
| Alt Symbol |
GH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
|
| Other Description |
gamma-Glu-X carboxypeptidase|gamma-glutamyl hydrolase
|
| Swissprots |
Q92820
|
| Accessions |
AAF03360 EAW86862 Q92820 AK290450 BAF83139 AK301094 BAG62694 BC025025 AAH25025 JF432643 ADZ15860 U55206 AAC05579 XM_011517623 XP_011515925 NM_003878 NP_003869
|
| Function |
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates.
|
| Subcellular Location |
Secreted, extracellular space. Lysosome. Melanosome. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Top Pathways |
Folate biosynthesis
|
![Western Blot: gamma-glutamyl hydrolase Overexpression Lysate (Adult Normal) [NBL1-11057] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for gamma-glutamyl hydrolase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5101_gamma-glutamyl%2520hydrolase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11057-img0002.jpg)