CD207

Gene Symbol	CD207
Entrez Gene	50489
Alt Symbol	CLEC4K
Species	Human
Gene Type	protein-coding
Description	CD207 molecule, langerin
Other Description	C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin
Swissprots	Q9UJ71
Accessions	EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532
Function	Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissue Specificity	Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Langerin (D9H7R) XP ® Rabbit mAb - 13650 from Cell Signaling Technology Prices $109.00, $277.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D9H7R

Langerin Antibody - 9484 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Langerin (H-4) - sc-271272 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Langerin (H-200) - sc-33767 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Langerin (E-17) - sc-22620 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Langerin (V-14) - sc-22623 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Langerin (N-14) - sc-22622 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Langerin [EPR15863] antibody - ab192027 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR15863

Anti-Langerin antibody - ab68434 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Langerin antibody - ab190634 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Langerin antibody - ab125476 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Langerin antibody [12D6] - ab49730 from Abcam Prices $392.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 12D6

Anti-CD207 / Langerin Antibody (aa64-328, PE) - LS-C125866 from LifeSpan Bioscience Prices $530.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-CD207 / Langerin Antibody (aa64-328, clone 11n124, PerCP) - LS-C184838 from LifeSpan Bioscience Prices $575.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 11n124

Anti-CD207 / Langerin Antibody - LS-C309794 from LifeSpan Bioscience Prices $475.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CD207 / Langerin Antibody - LS-C309795 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CD207 / Langerin Antibody - LS-C306810 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CD207 / Langerin Antibody (clone 12D6, Ready-to-Use) - LS-C348505 from LifeSpan Bioscience Prices $255.00, $325.00, $465.00 Sizes 3 ml, 7 ml, 15 ml Host Mouse Clonality Monoclonal Clone 12D6

Anti-CD207 / Langerin Antibody - LS-C335688 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CD207 / Langerin Antibody (clone 12D6) - LS-C312086 from LifeSpan Bioscience Prices $255.00, $405.00, $560.00 Sizes 100 µl, 500 µl, 1 ml Host Mouse Clonality Monoclonal Clone 12D6

Anti-CD207 / Langerin Antibody (C-Terminus) - LS-C146446 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CD207 / Langerin Antibody (aa26-44) - LS-C735 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Langerin/CD207 Antibody - AF2088 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Langerin/CD207 Antibody (808E10.01) - DDX0360P-100 from Novus Biologicals Prices $279.00, $329.00 Sizes 50 µg, 100 µg Host Mouse Clonality Monoclonal Clone 808E10.01

Langerin/CD207 Antibody (929F3.01) - DDX0362P-100 from Novus Biologicals Prices $279.00, $369.00 Sizes 50 µg, 100 µg Host Rat Clonality Monoclonal Clone 929F3.01

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