| Gene Symbol |
CD207
|
| Entrez Gene |
50489
|
| Alt Symbol |
CLEC4K
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD207 molecule, langerin
|
| Other Description |
C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin
|
| Swissprots |
Q9UJ71
|
| Accessions |
EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532
|
| Function |
Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
|
| Tissue Specificity |
Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}.
|
![Western Blot: Langerin Overexpression Lysate (Adult Normal) [NBL1-08920] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Langerin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7998_Langerin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08920-img0002.jpg)