| Gene Symbol | CD207 |
|---|---|
| Entrez Gene | 50489 |
| Alt Symbol | CLEC4K |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD207 molecule, langerin |
| Other Description | C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin |
| Swissprots | Q9UJ71 |
| Accessions | EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532 |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. |
| Tissue Specificity | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}. |