CD207

Gene Symbol CD207
Entrez Gene 50489
Alt Symbol CLEC4K
Species Human
Gene Type protein-coding
Description CD207 molecule, langerin
Other Description C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin
Swissprots Q9UJ71
Accessions EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532
Function Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.
Subcellular Location Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissue Specificity Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}.

Langerin CRISPR/Cas9 KO Plasmid (h) - sc-401949 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin HDR Plasmid (h) - sc-401949-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin Double Nickase Plasmid (h) - sc-401949-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin Double Nickase Plasmid (h2) - sc-401949-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin CRISPR Activation Plasmid (h) - sc-401949-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin CRISPR Activation Plasmid (h2) - sc-401949-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin Lentiviral Activation Particles (h) - sc-401949-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin Lentiviral Activation Particles (h2) - sc-401949-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Langerin siRNA (h) - sc-43888 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Langerin shRNA Plasmid (h) - sc-43888-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Langerin shRNA (h) Lentiviral Particles - sc-43888-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU149991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5698 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5698 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12361 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12361

CD207 siRNA (Human) - CRH9375 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CD207 - MBS8231411 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CD207 (NM_015717.3) - SHH258673 from Creative biogene

Category siRNA
Species Reactivities Human

CD207 shRNA Plasmid (Human) - CHH9375 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CD207 miRNA 3'UTR clone - MiUTR3H-07146 from Creative biogene

Species Reactivities Human
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