Gene Symbol | CD207 |
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Entrez Gene | 50489 |
Alt Symbol | CLEC4K |
Species | Human |
Gene Type | protein-coding |
Description | CD207 molecule, langerin |
Other Description | C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin |
Swissprots | Q9UJ71 |
Accessions | EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532 |
Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes. |
Tissue Specificity | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}. |
Langerin CRISPR/Cas9 KO Plasmid (h) - sc-401949 from Santa Cruz Biotechnology
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Langerin HDR Plasmid (h) - sc-401949-HDR from Santa Cruz Biotechnology
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Langerin Double Nickase Plasmid (h) - sc-401949-NIC from Santa Cruz Biotechnology
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Langerin Double Nickase Plasmid (h2) - sc-401949-NIC-2 from Santa Cruz Biotechnology
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Langerin CRISPR Activation Plasmid (h) - sc-401949-ACT from Santa Cruz Biotechnology
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Langerin CRISPR Activation Plasmid (h2) - sc-401949-ACT-2 from Santa Cruz Biotechnology
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Langerin Lentiviral Activation Particles (h) - sc-401949-LAC from Santa Cruz Biotechnology
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Langerin Lentiviral Activation Particles (h2) - sc-401949-LAC-2 from Santa Cruz Biotechnology
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Langerin siRNA (h) - sc-43888 from Santa Cruz Biotechnology
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Langerin shRNA Plasmid (h) - sc-43888-SH from Santa Cruz Biotechnology
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Langerin shRNA (h) Lentiviral Particles - sc-43888-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU149991 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5698 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5698 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12361 from Sigma-Aldrich
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CD207 siRNA (Human) - CRH9375 from Cohesion Biosciences
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CD207 - MBS8231411 from MyBioSource
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shRNA set against Human CD207 (NM_015717.3) - SHH258673 from Creative biogene
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CD207 shRNA Plasmid (Human) - CHH9375 from Cohesion Biosciences
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CD207 miRNA 3'UTR clone - MiUTR3H-07146 from Creative biogene
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