CD207

Gene Symbol	CD207
Entrez Gene	50489
Alt Symbol	CLEC4K
Species	Human
Gene Type	protein-coding
Description	CD207 molecule, langerin
Other Description	C-type lectin domain family 4 member K|C-type lectin domain family 4, member K|CD207 antigen, langerin|Langerhans cell specific c-type lectin
Swissprots	Q9UJ71
Accessions	EAW99793 Q9UJ71 AJ242859 CAB62403 AK314927 BAG37434 BC022278 AAH22278 BX104865 DQ891964 ABM82890 DQ895154 ABM86080 XM_011532874 XP_011531176 XM_011532875 XP_011531177 XM_011532876 XP_011531178 NM_015717 NP_056532
Function	Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:17334373, ECO:0000269|PubMed:20026605, ECO:0000269|PubMed:20097424}.
Subcellular Location	Membrane {ECO:0000269|PubMed:10661407}; Single-pass type II membrane protein {ECO:0000269|PubMed:10661407}. Note=Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.
Tissue Specificity	Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. {ECO:0000269|PubMed:10661407, ECO:0000269|PubMed:20026605}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Langerin full length protein - ab132256 from Abcam Category Protein Source Wheat germ Species Human

Human Langerin peptide - ab73966 from Abcam Category Peptide

Human Langerin protein fragment - ab202625 from Abcam Category Protein Source E. coli Species Human

CD207 / Langerin Antibody Blocking Peptide - LS-E23161 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Langerin/CD207 Recombinant Protein - H00050489-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Langerin/CD207 Recombinant Protein - H00050489-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

Recombinant Human Langerin/CD207, CF - 2088-LN-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Tyr64-Pro328, with an N-terminal 9-His tag

CD207 protein (His tag) - 80R-4179 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

CD207 / Langerin (65-328, His-tag) - AR51867PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

CD207 / Langerin (65-328, His-tag) - AR51867PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

CD207 / Langerin - H00050489-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD207 / Langerin - H00050489-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD207 / Langerin - H00050489-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD207 fusion protein - Ag2479 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CD207 Molecule, Langerin, His-tagged - CD207-5607H from Creative Biomart Category Protein Source Murine myeloma cellline, NS0-derived

Recombinant Human CD207, GST-tagged - CD207-10924H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant C-Type Lectin Domain Family 4, Member K (CLEC4K) - RPB602Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant C-Type Lectin Domain Family 4, Member K (CLEC4K) - RPB602Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human C-type lectin domain family 4 member K(CD207) - CSB-YP892321HU CSB-EP892321HU CSB-BP892321HU CSB-MP892321HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CD207, 65-328aa, Human, His tag, E.coli (Denatured) - ATGP3047 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Recombinant Human Langerin/CD207 Protein, CF - 2088-LN from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Tyr64-Pro328, with an N-terminal 9-His tag Species Human

CD207 / Langerin - TP304669 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

C-type lectin domain family 4 member K (CD207), Recombinant Protein - MBS1391127 from MyBioSource Category Protein Prices $1,015.00, $1,015.00, $1,245.00, $1,245.00, $1,565.00, $1,565.00, $2,030.00, $2,030.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

CD207, Recombinant Protein - MBS205832 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

Recombinant Human CD207 protein, MYC/DDK-tagged - CD207-315H from Creative Biomart Category Protein Source HEK293 Species Human

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