NLRC4

Gene Symbol	NLRC4
Entrez Gene	58484
Alt Symbol	AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Species	Human
Gene Type	protein-coding
Description	NLR family, CARD domain containing 4
Other Description	CARD, LRR, and NACHT-containing protein\|ICE-protease activating factor\|NLR family CARD domain-containing protein 4\|NOD-like receptor C4\|caspase recruitment domain family, member 12\|caspase recruitment domain-containing protein 12\|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Swissprots	Q96J81 A8K9F8 Q96J83 D6W580 Q9NPP4 Q96J82 B3KTF0 B2RBQ3
Accessions	EAX00451 EAX00452 EAX00453 EAX00454 EAX00455 Q9NPP4 AF376061 AAK53443 AK095467 BAG53062 AK292673 BAF85362 AK314762 BAG37300 AL389934 CAB97523 AW337918 AY027787 AAK14776 AY027788 AAK14777 AY027789 AAK14778 AY027790 AAK14779 AY032589 AAK38730 AY035391 AAK59843 AY358152 AAQ88519 BC031555 AAH31555 DN998613 EU832133 ACE87483 EU832226 ACE86796 XM_011533008 XP_011531310 NM_001199138 NP_001186067 NM_001199139 NP_001186068 NM_001302504 NP_001289433 NM_021209 NP_067032
Function	Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269\|PubMed:15107016}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
Tissue Specificity	Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
Top Pathways	NOD-like receptor signaling pathway, Salmonella infection, Legionellosis

NLRC4 (D5Y8E) Rabbit mAb - 12421 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D5Y8E

Western blot analysis of extracts from THP-1 and MUTZ-3 cells using NLRC4 (D5Y8E) Rabbit mAb.

CARD 12 (K-18) - sc-49395 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CARD 12 (K-18): sc-49395. Western blot analysis of CARD 12 expression in IMR-32 whole cell lysate.

CARD 12 (H-123) - sc-99056 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CARD 12 (H-123): sc-99056. Immunoperoxidase staining of formalin fixed, paraffin-embedded human smooth muscle tissue showing cytoplasmic staining of smooth muscle cells.

CARD 12 (F-18) - sc-49394 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CARD 12 (N-20) - sc-49396 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CARD 12 (N-20): sc-49396. Western blot analysis of CARD 12 expression in IMR-32 whole cell lysate.

Anti-CARD12 antibody - ab99860 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CARD12 antibody (ab99860) at 1/500 dilution + Human fetal brain lysate

Anti-CARD12 antibody - ab115537 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115537 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CARD12 antibody - ab21301 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1 : Anti-CARD12 antibody (ab21301) at 0.5 µg/mlLane 2 : Anti-CARD12 antibody (ab21301) at 1 µg/mlLane 3 : Anti-CARD12 antibody (ab21301) at 2 µg/mlLane 1 : Human PBL lysate 15ugLane 2 : Human PBL lysate 15ugLane 3 : Human PBL lysate 15ug

Anti-CARD12 antibody - ab189593 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CARD12 antibody (ab189593) at 1/1000 dilutionLane 1 : HeLa cell extractLane 2 : Jurkat cell extract

Anti-CARD12 antibody - N-terminal - ab154960 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CARD12 antibody - N-terminal (ab154960) at 1/1000 dilution + MCF7 whole cell lysate at 30 µg

Anti-IPAF / NLRC4 Antibody (C-Terminus) - LS-C7477 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (aa1-10) - LS-C40686 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody - LS-C22241 from LifeSpan Bioscience

Prices	$325.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody - LS-C68328 from LifeSpan Bioscience

Prices	$545.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (C-Terminus) - LS-C121967 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody - LS-C148271 from LifeSpan Bioscience

Prices	$335.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody - LS-C150719 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody - LS-C150720 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (Biotin) - LS-C180944 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (DY650) - LS-C180945 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (aa941-990) - LS-C29800 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (DY488) - LS-C180946 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (DY550) - LS-C180947 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-IPAF / NLRC4 Antibody (aa1-17) - LS-C49327 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of CLAN in lung lysate with anti-CLAN at a 1:500 dilution. Detects CLAN-A and CLAN-B isoforms.

Anti-IPAF / NLRC4 Antibody (Biotin) - LS-C180948 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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