NLRC4

Gene Symbol NLRC4
Entrez Gene 58484
Alt Symbol AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Species Human
Gene Type protein-coding
Description NLR family, CARD domain containing 4
Other Description CARD, LRR, and NACHT-containing protein|ICE-protease activating factor|NLR family CARD domain-containing protein 4|NOD-like receptor C4|caspase recruitment domain family, member 12|caspase recruitment domain-containing protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Swissprots Q96J81 A8K9F8 Q96J83 D6W580 Q9NPP4 Q96J82 B3KTF0 B2RBQ3
Accessions EAX00451 EAX00452 EAX00453 EAX00454 EAX00455 Q9NPP4 AF376061 AAK53443 AK095467 BAG53062 AK292673 BAF85362 AK314762 BAG37300 AL389934 CAB97523 AW337918 AY027787 AAK14776 AY027788 AAK14777 AY027789 AAK14778 AY027790 AAK14779 AY032589 AAK38730 AY035391 AAK59843 AY358152 AAQ88519 BC031555 AAH31555 DN998613 EU832133 ACE87483 EU832226 ACE86796 XM_011533008 XP_011531310 NM_001199138 NP_001186067 NM_001199139 NP_001186068 NM_001302504 NP_001289433 NM_021209 NP_067032
Function Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
Tissue Specificity Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
Top Pathways NOD-like receptor signaling pathway, Salmonella infection, Legionellosis

CARD 12 CRISPR/Cas9 KO Plasmid (h) - sc-418306 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 HDR Plasmid (h) - sc-418306-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 Double Nickase Plasmid (h) - sc-418306-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 Double Nickase Plasmid (h2) - sc-418306-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 CRISPR Activation Plasmid (h) - sc-418306-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 CRISPR Activation Plasmid (h2) - sc-418306-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 Lentiviral Activation Particles (h) - sc-418306-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 Lentiviral Activation Particles (h2) - sc-418306-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CARD 12 siRNA (h) - sc-60328 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CARD 12 shRNA Plasmid (h) - sc-60328-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CARD 12 shRNA (h) Lentiviral Particles - sc-60328-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CARD12 RNAi - H00058484-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU071221 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15346 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15346 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NLRC4 siRNA (Human) - CRJ1714 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NLRC4 (NM_021209.4) - SHH352872 from Creative biogene

Category siRNA
Species Reactivities Human

Human NLRC4 siRNA - orb272215 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NLRC4 shRNA Plasmid (Human) - CHJ1714 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NLRC4 miRNA 3'UTR clone - MiUTR4H-TG06032 from Creative biogene

Species Reactivities Human
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