NLRC4

Gene Symbol NLRC4
Entrez Gene 58484
Alt Symbol AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Species Human
Gene Type protein-coding
Description NLR family, CARD domain containing 4
Other Description CARD, LRR, and NACHT-containing protein|ICE-protease activating factor|NLR family CARD domain-containing protein 4|NOD-like receptor C4|caspase recruitment domain family, member 12|caspase recruitment domain-containing protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Swissprots Q96J81 A8K9F8 Q96J83 D6W580 Q9NPP4 Q96J82 B3KTF0 B2RBQ3
Accessions EAX00451 EAX00452 EAX00453 EAX00454 EAX00455 Q9NPP4 AF376061 AAK53443 AK095467 BAG53062 AK292673 BAF85362 AK314762 BAG37300 AL389934 CAB97523 AW337918 AY027787 AAK14776 AY027788 AAK14777 AY027789 AAK14778 AY027790 AAK14779 AY032589 AAK38730 AY035391 AAK59843 AY358152 AAQ88519 BC031555 AAH31555 DN998613 EU832133 ACE87483 EU832226 ACE86796 XM_011533008 XP_011531310 NM_001199138 NP_001186067 NM_001199139 NP_001186068 NM_001302504 NP_001289433 NM_021209 NP_067032
Function Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
Tissue Specificity Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
Top Pathways NOD-like receptor signaling pathway, Salmonella infection, Legionellosis

NLR family CARD domain-containing protein 4 (NLRC4), Human, ELISA Kit - CSB-EL015862HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

NLR family CARD domain-containing protein 4, NLRC4, Human, ELISA Kit - E1535h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

ICE protease-activating factor (IRAP), ELISA Kit - MBS261376 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS2600488 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS260922 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00, $1,615.00, $2,880.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS266566 from MyBioSource

Category ELISA Kit
Prices $290.00, $450.00, $1,755.00, $3,150.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.05 ng/ml.
Range 10 ng/ml-0.156ng/ml

ICE protease-activating factor (IRAP), ELISA Kit - MBS263364 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS263878 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS262603 from MyBioSource

Category ELISA Kit
Prices $315.00, $490.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ICE protease-activating factor (IRAP), ELISA Kit - MBS264146 from MyBioSource

Category ELISA Kit
Prices $290.00, $450.00, $1,755.00, $3,150.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.05 ng/ml.
Range 10 ng/ml-0.156 ng/ml

ICE protease-activating factor, IRAP, ELISA Kit - MBS9303561 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

NLR family, CARD domain containing 4, ELISA Kit - MBS919421 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human NLR family CARD domain-containing protein 4(NLRC4) ELISA kit - CSB-EL015862HU from Cusabio

Category ELISA Kit
Sensitivity 3.9 pg/ml
Range 15.6 pg/ml - 1000 pg /ml

Mouse IPAF / NLRC4 ELISA Kit (Sandwich ELISA) - LS-F17939 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Bovine IPAF / NLRC4 ELISA Kit (Custom ELISA) - LS-F17936 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Rat IPAF / NLRC4 ELISA Kit (Custom ELISA) - LS-F17938 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human IPAF / NLRC4 ELISA Kit (Custom ELISA) - LS-F17937 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 0.156-10 ng/ml

Human NLRC4(NLR family CARD domain-containing protein 4) ELISA Kit - E-EL-H5599 from Elabscience

Category ELISA Kit
Sensitivity 46.88 pg/mL
Range 78.13—5000 pg/mL

NLRC4 - EKH3592 from Nordic BioSite

Sensitivity 46.9pg/ml
Range 78-5000pg/ml

NLRC4 ELISA Kit (Human) : 96 Wells (OKEH01101) - OKEH01101 from Aviva Systems Biology

Category ELISA Kit
Prices $420.00
Sizes 96 wells
Sensitivity < 39 pg/mL
Range 78 - 5000 pg/mL

Human NLRC4 ELISA Kit - E026656 from Biobool

Category ELISA Kit
Sensitivity <46.9pg/ml

Human NLR family CARD domain-containing protein 4 ELISA Kit - EK3767 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.156-10 ng/ml

Human NLRC4(NLR family CARD domain-containing protein 4) ELISA Kit - E-EL-H5599 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 46.88 pg/mL
Range 78.13~5000 pg/mL

ICE protease-activating factor (IRAP), ELISA Kit - MBS2609387 from MyBioSource

Category ELISA Kit
Prices $300.00, $475.00, $1,825.00, $3,425.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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