| Gene Symbol |
NLRC4
|
| Entrez Gene |
58484
|
| Alt Symbol |
AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NLR family, CARD domain containing 4
|
| Other Description |
CARD, LRR, and NACHT-containing protein|ICE-protease activating factor|NLR family CARD domain-containing protein 4|NOD-like receptor C4|caspase recruitment domain family, member 12|caspase recruitment domain-containing protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
|
| Swissprots |
Q96J81 A8K9F8 Q96J83 D6W580 Q9NPP4 Q96J82 B3KTF0 B2RBQ3
|
| Accessions |
EAX00451 EAX00452 EAX00453 EAX00454 EAX00455 Q9NPP4 AF376061 AAK53443 AK095467 BAG53062 AK292673 BAF85362 AK314762 BAG37300 AL389934 CAB97523 AW337918 AY027787 AAK14776 AY027788 AAK14777 AY027789 AAK14778 AY027790 AAK14779 AY032589 AAK38730 AY035391 AAK59843 AY358152 AAQ88519 BC031555 AAH31555 DN998613 EU832133 ACE87483 EU832226 ACE86796 XM_011533008 XP_011531310 NM_001199138 NP_001186067 NM_001199139 NP_001186068 NM_001302504 NP_001289433 NM_021209 NP_067032
|
| Function |
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
|
| Tissue Specificity |
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
|
| Top Pathways |
NOD-like receptor signaling pathway, Salmonella infection, Legionellosis
|