NLRC4

Gene Symbol	NLRC4
Entrez Gene	58484
Alt Symbol	AIFEC, CARD12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, FCAS4, IPAF
Species	Human
Gene Type	protein-coding
Description	NLR family, CARD domain containing 4
Other Description	CARD, LRR, and NACHT-containing protein|ICE-protease activating factor|NLR family CARD domain-containing protein 4|NOD-like receptor C4|caspase recruitment domain family, member 12|caspase recruitment domain-containing protein 12|nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
Swissprots	Q96J81 A8K9F8 Q96J83 D6W580 Q9NPP4 Q96J82 B3KTF0 B2RBQ3
Accessions	EAX00451 EAX00452 EAX00453 EAX00454 EAX00455 Q9NPP4 AF376061 AAK53443 AK095467 BAG53062 AK292673 BAF85362 AK314762 BAG37300 AL389934 CAB97523 AW337918 AY027787 AAK14776 AY027788 AAK14777 AY027789 AAK14778 AY027790 AAK14779 AY032589 AAK38730 AY035391 AAK59843 AY358152 AAQ88519 BC031555 AAH31555 DN998613 EU832133 ACE87483 EU832226 ACE86796 XM_011533008 XP_011531310 NM_001199138 NP_001186067 NM_001199139 NP_001186068 NM_001302504 NP_001289433 NM_021209 NP_067032
Function	Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269|PubMed:15107016}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
Tissue Specificity	Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
Top Pathways	NOD-like receptor signaling pathway, Salmonella infection, Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CARD12 peptide - ab39780 from Abcam Category Peptide Prices $290.00 Sizes 50 µg Species Human

Human CARD12 protein fragment - ab127060 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

IPAF / NLRC4 Antibody Blocking Peptide - LS-E2343 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IPAF / NLRC4 Antibody Blocking Peptide - LS-E30011 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human CARD12 Protein - H00058484-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NLRC4-Antibody-N-term-Blocking-peptide - BP13307a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CARD12 Blocking Peptide - 33R-7636 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NLRC4 - H00058484-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

NLRC4 - H00058484-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NLRC4 Control Peptide - AP30437CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Ipaf Peptide - 3107P from ProSci Category Peptide Species Human

IPAF fusion protein - ag4048 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IPAF fusion protein - Ag14406 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human NLRC4 - NLRC4-815H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human NLR family CARD domain-containing protein 4(NLRC4) ,partial - CSB-YP873615HU CSB-EP873615HU CSB-BP873615HU CSB-MP873615HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NLRC4 (a.a. 525-538) - NX5385 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

NLRC4 Protein - abx163868 from Abbexa Category Protein Species Human

Ice Protease Activating Factor, Peptide - MBS657974 from MyBioSource Category Peptide Prices $280.00 Sizes 50 µg

CARD12 Protein - NBP2-13660PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

NLRC4 Peptide, Human - M34GP10430H from Creative Peptides Category Peptide Source Synthetic. Species Human

NLR family CARD domain-containing protein 4 (NLRC4), partial, Recombinant Protein - MBS1376374 from MyBioSource Category Protein Prices $1,750.00, $1,750.00, $2,205.00, $2,205.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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