| Gene Symbol |
TEAD4
|
| Entrez Gene |
7004
|
| Alt Symbol |
EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TEA domain family member 4
|
| Other Description |
related transcription enhancer factor 1B|transcription factor 13-like 1|transcription factor RTEF-1|transcriptional enhancer factor 1-related|transcriptional enhancer factor 3|transcriptional enhancer factor TEF-3
|
| Swissprots |
Q6MZR9 Q96BK2 Q92883 Q15561 H0Y308 Q8NEV5
|
| Accessions |
EAW88872 EAW88873 EAW88874 EAW88875 Q15561 AK222947 BAD96667 AY101179 AAM89497 BC015497 AAH15497 BM464237 BM555991 BX640921 CAE45959 DA210894 DA886817 EU446502 ABZ92031 U63824 AAC50763 X94438 CAA64212 NM_003213 NP_003204 NM_201441 NP_958849 NM_201443 NP_958851
|
| Function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
|
| Top Pathways |
Hippo signaling pathway
|