TEAD4

Gene Symbol TEAD4
Entrez Gene 7004
Alt Symbol EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
Species Human
Gene Type protein-coding
Description TEA domain family member 4
Other Description related transcription enhancer factor 1B|transcription factor 13-like 1|transcription factor RTEF-1|transcriptional enhancer factor 1-related|transcriptional enhancer factor 3|transcriptional enhancer factor TEF-3
Swissprots Q6MZR9 Q96BK2 Q92883 Q15561 H0Y308 Q8NEV5
Accessions EAW88872 EAW88873 EAW88874 EAW88875 Q15561 AK222947 BAD96667 AY101179 AAM89497 BC015497 AAH15497 BM464237 BM555991 BX640921 CAE45959 DA210894 DA886817 EU446502 ABZ92031 U63824 AAC50763 X94438 CAA64212 NM_003213 NP_003204 NM_201441 NP_958849 NM_201443 NP_958851
Function Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Subcellular Location Nucleus.
Tissue Specificity Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Top Pathways Hippo signaling pathway

TEF-3 (B-5) - sc-390578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TEF-3 (B-5): sc-390578. Western blot analysis of TEF-3 expression in non-transfected: sc-110760 (A) and human TEF-3 transfected: sc-113218 (B) 293T whole cell lysates.

TEF-3 (H-38) - sc-292764 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

TEF-3 (N-14) - sc-109081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TEF-3 (N-14): sc-109081. Western blot analysis of TEF-3 expression in non-transfected: sc-110760 (A) and human TEF-3 transfected: sc-113218 (B) 293 whole cell lysates.

TEF-3 (N-G2) - sc-101184 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TEF-3 (N-G2): sc-101184. Western blot analysis of TEF-3 expression in non-transfected: sc-110760 (A) and human TEF-3 transfected: sc-113218 (B) 293 whole cell lysates.

TEF-3 (W-21) - sc-134071 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
TEF-3 (W-21): sc-134071. Western blot analysis of human TEF-3 transfected 293T whole cell lysate.

Anti-TEAD4 antibody - ab97460 from Abcam

Prices $385.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-TEAD4 antibody (ab97460) at 1/1000 dilution + HepG2 cell lysate at 30 µg

Anti-TEAD4 antibody - ab58308 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
TEAD4 antibody (ab58308) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-TEAD4 antibody - ab151274 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TEAD4 antibody (ab151274) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : HUES7 (Human embryonic stem cell line) Whole Cell LysateLane 3 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLane 4 : SW480 (Human colon adenocarcinoma cell line) Whole Cell LysateLane 5 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 6 : HCT 116 (Human Colorectal Carcinoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TEAD4 antibody - ab110796 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TEAD4 antibody (ab110796) at 1 µg/mlLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : HUES7 (Human embryonic stem cell line) Whole Cell Lysate Lane 3 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLane 4 : SW480 (Human colon adenocarcinoma cell line) Whole Cell LysateLane 5 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 6 : HCT 116 (Human Colorectal Carcinoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TEAD4 antibody - ChIP Grade - ab58310 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TEAD4 Antibody (C-Terminus) IHC-plus™ - LS-B3522 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TEAD4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3522 concentration 5 ug/ml.

Anti-TEAD4 Antibody (aa151-261, Azide-free) - LS-C328857 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-TEAD4 Antibody (clone 1D10) - LS-C133476 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D10
TEAD4 monoclonal antibody (M12), clone 1D10. Western blot of TEAD4 expression in human spleen.

Anti-TEAD4 Antibody (aa100-149) - LS-C145533 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TEAD4 antibody LS-C145533 Western blot of Mouse Intestine lysate. Antibody concentration 1 ug/ml.

Anti-TEAD4 Antibody (aa252-301) - LS-C101448 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
TEAD4 antibody LS-C101448 Western blot of Transfected 293T cell lysate.

Anti-TEAD4 Antibody (N-Terminus) - LS-C201337 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Thyroid Tumor. TEAD4 antibody dilution 1.0 ug/ml.

Anti-TEAD4 Antibody (aa1-260) - LS-C186024 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SW480 xenograft using TEAD4 antibody at 1:500 dilution.

TEAD4 Antibody (5H3) - H00007004-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5H3
Western Blot: TEAD4 Antibody (5H3) [H00007004-M01] - TEAD4 monoclonal antibody (M01), clone 5H3 Analysis of TEAD4 expression in HeLa.

TEAD4 Antibody - NBP1-32765 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TEAD4 Antibody - NBP2-33803 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TEAD4 Antibody - NBP2-20590 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

TEAD4 Antibody - H00007004-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TEAD4 Antibody [H00007004-B01] - Immunofluorescence of purified MaxPab antibody to TEAD4 ( Cat# H00007004-B01 ) on HeLa cell . [antibody concentration 10 ug/ml]

TEAD4 Antibody - H00007004-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: TEAD4 Antibody [H00007004-B01P] - Analysis of TEAD4 expression in transfected 293T cell line by TEAD4 polyclonal antibody. Lane 1: TEAD4 transfected lysate(33.55 KDa). Lane 2: Non-transfected lysate.

TEAD4 Antibody (1D10) - H00007004-M12 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D10
Western Blot: TEAD4 Antibody (1D10) [H00007004-M12] - Analysis of TEAD4 expression in human spleen.

TEAD4 Antibody - H00007004-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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