TEAD4

Gene Symbol	TEAD4
Entrez Gene	7004
Alt Symbol	EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
Species	Human
Gene Type	protein-coding
Description	TEA domain family member 4
Other Description	related transcription enhancer factor 1B|transcription factor 13-like 1|transcription factor RTEF-1|transcriptional enhancer factor 1-related|transcriptional enhancer factor 3|transcriptional enhancer factor TEF-3
Swissprots	Q6MZR9 Q96BK2 Q92883 Q15561 H0Y308 Q8NEV5
Accessions	EAW88872 EAW88873 EAW88874 EAW88875 Q15561 AK222947 BAD96667 AY101179 AAM89497 BC015497 AAH15497 BM464237 BM555991 BX640921 CAE45959 DA210894 DA886817 EU446502 ABZ92031 U63824 AAC50763 X94438 CAA64212 NM_003213 NP_003204 NM_201441 NP_958849 NM_201443 NP_958851
Function	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Subcellular Location	Nucleus.
Tissue Specificity	Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TEAD4 protein fragment - ab152733 from Abcam Category Protein Source Wheat germ Species Human

Human TEAD4 protein fragment - ab152734 from Abcam Category Protein Source Wheat germ Species Human

TEAD4 Antibody Blocking Peptide - LS-E11808 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TEAD4 Antibody Blocking Peptide - LS-E11809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TEAD4 Antibody Blocking Peptide - LS-E13749 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TEAD4 Protein - H00007004-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TEAD4 Protein - H00007004-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human TEAD4 protein - orb244808 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

Tead4 Blocking Peptide - 33R-10394 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TEAD4 / TEF3 / RTEF1 - H00007004-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TEAD4 / TEF3 / RTEF1 - H00007004-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TEAD4 / TEF3 / RTEF1 - H00007004-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TEAD4 / TEF3 / RTEF1 - H00007004-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TEAD4 fusion protein - Ag3059 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human TEAD4, GST-tagged - TEAD4-3175H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant human Transcriptional enhancer factor TEF-3 - CSB-EP618010HU CSB-BP618010HU CSB-MP618010HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Transcriptional enhancer factor TEF-3 - CSB-EP618010HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Transcriptional enhancer factor TEF-3(TEAD4) - CSB-YP618010HU CSB-BP618010HU CSB-MP618010HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

TEAD4 Recombinant Protein Antigen - NBP2-33803PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TEAD4 Peptide, Human - M34GP15772H from Creative Peptides Category Peptide Source Synthetic. Species Human

TEAD4 Recombinant Protein (OPCA02240) - OPCA02240 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Transcriptional enhancer factor TEF-3 - AP71265 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Human TEAD4 protein - orb418762 from Biorbyt Category Protein Species Human

Recombinant Human TEAD4 Protein (74-434 aa), His-SUMO-tagged - TEAD4-1005H from Creative Biomart Category Protein Source E. coli Species Human

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