TEAD4

Gene Symbol	TEAD4
Entrez Gene	7004
Alt Symbol	EFTR-2, RTEF1, TCF13L1, TEF-3, TEF3, TEFR-1, hRTEF-1B
Species	Human
Gene Type	protein-coding
Description	TEA domain family member 4
Other Description	related transcription enhancer factor 1B|transcription factor 13-like 1|transcription factor RTEF-1|transcriptional enhancer factor 1-related|transcriptional enhancer factor 3|transcriptional enhancer factor TEF-3
Swissprots	Q6MZR9 Q96BK2 Q92883 Q15561 H0Y308 Q8NEV5
Accessions	EAW88872 EAW88873 EAW88874 EAW88875 Q15561 AK222947 BAD96667 AY101179 AAM89497 BC015497 AAH15497 BM464237 BM555991 BX640921 CAE45959 DA210894 DA886817 EU446502 ABZ92031 U63824 AAC50763 X94438 CAA64212 NM_003213 NP_003204 NM_201441 NP_958849 NM_201443 NP_958851
Function	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
Subcellular Location	Nucleus.
Tissue Specificity	Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Top Pathways	Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TEF-3 CRISPR/Cas9 KO Plasmid (h) - sc-402093 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 HDR Plasmid (h) - sc-402093-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 Double Nickase Plasmid (h) - sc-402093-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 Double Nickase Plasmid (h2) - sc-402093-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 CRISPR Activation Plasmid (h) - sc-402093-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 CRISPR Activation Plasmid (h2) - sc-402093-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 Lentiviral Activation Particles (h) - sc-402093-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 Lentiviral Activation Particles (h2) - sc-402093-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TEF-3 siRNA (h) - sc-96187 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TEF-3 shRNA Plasmid (h) - sc-96187-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TEF-3 shRNA (h) Lentiviral Particles - sc-96187-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TEAD4 RNAi - H00007004-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TEAD4 RNAi - H00007004-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TEAD4 RNAi - H00007004-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN21198 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21198 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01067 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr01067

TEAD4 siRNA (Human) - CRH4781 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TEAD4 RNAi - H00007004-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

TEAD4 - MBS8230136 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TEAD4 (NM_003213.3) - SHH425460 from Creative biogene Category siRNA Species Reactivities Human

TEAD4 shRNA Plasmid (Human) - CHH4781 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TEAD4 miRNA 3'UTR clone - MiUTR3H-04335 from Creative biogene Species Reactivities Human

TEAD4 miRNA 3'UTR clone - MiUTR3H-04336 from Creative biogene Species Reactivities Human

TEAD4 miRNA 3'UTR clone - MiUTR3H-04337 from Creative biogene Species Reactivities Human

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