PFN2

Gene Symbol	PFN2
Entrez Gene	5217
Alt Symbol	D3S1319E, PFL
Species	Human
Gene Type	protein-coding
Description	profilin 2
Other Description	profilin II|profilin-2
Swissprots	Q8WVF9 D3DNI4 Q9HBK2 B2R4C8 P35080 Q4VBQ4
Accessions	EAW78850 EAW78851 EAW78852 EAW78853 EAW78854 EAW78855 EAW78856 P35080 AF228738 AAG24949 AK297915 BAG60233 AK307227 AK311780 BAG34723 AK311782 BAG34725 AL096719 BC002964 BC018049 AAH18049 BC043646 AAH43646 BC095444 AAH95444 BX463350 EU832616 ACE87707 EU832688 ACE87020 L10678 AAA03022 NM_002628 NP_002619 NM_053024 NP_444252
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Top Pathways	Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PFN2-Over-expression-Lysate - LY14242a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PFN2 overexpression lysate - LY400933 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PFN2 overexpression lysate - LY409326 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

PFN2 293 Cell Lysate - 404935 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PFN2 293 Cell Lysate - 400878 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Profilin 2 Overexpression Lysate (Native) - NBL1-14320 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Profilin 2 Overexpression Lysate (Native) - NBL1-14319 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Profilin-2 (h): 293T Lysate - sc-177780 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PFN2 Over-expression Lysate Product - GWB-73E816 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

PFN2 Over-expression Lysate Product - GWB-10D24A from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human PFN2 Knockdown Stable Cell Line - CSC-DC011632 from Creative biogene Category Cell Line Species Human

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