PFN2

Gene Symbol	PFN2
Entrez Gene	5217
Alt Symbol	D3S1319E, PFL
Species	Human
Gene Type	protein-coding
Description	profilin 2
Other Description	profilin II|profilin-2
Swissprots	Q8WVF9 D3DNI4 Q9HBK2 B2R4C8 P35080 Q4VBQ4
Accessions	EAW78850 EAW78851 EAW78852 EAW78853 EAW78854 EAW78855 EAW78856 P35080 AF228738 AAG24949 AK297915 BAG60233 AK307227 AK311780 BAG34723 AK311782 BAG34725 AL096719 BC002964 BC018049 AAH18049 BC043646 AAH43646 BC095444 AAH95444 BX463350 EU832616 ACE87707 EU832688 ACE87020 L10678 AAA03022 NM_002628 NP_002619 NM_053024 NP_444252
Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Top Pathways	Salmonella infection, Rap1 signaling pathway, Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Profilin-2 CRISPR/Cas9 KO Plasmid (h) - sc-403456 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 HDR Plasmid (h) - sc-403456-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 Double Nickase Plasmid (h) - sc-403456-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 Double Nickase Plasmid (h2) - sc-403456-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 CRISPR Activation Plasmid (h) - sc-403456-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 CRISPR Activation Plasmid (h2) - sc-403456-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 Lentiviral Activation Particles (h) - sc-403456-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 Lentiviral Activation Particles (h2) - sc-403456-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 siRNA (h) - sc-78482 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Profilin-2 shRNA Plasmid (h) - sc-78482-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Profilin-2 shRNA (h) Lentiviral Particles - sc-78482-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Profilin 2 RNAi - H00005217-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

Profilin 2 RNAi - H00005217-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU011431 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16662 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16662 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10047 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10047

PFN2 siRNA (Human) - CRH3486 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Profilin-2 CRISPR/Cas9 KO Plasmid (h2) - sc-403456-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Profilin-2 HDR Plasmid (h2) - sc-403456-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human PFN2 (NM_002628.4) - SHH374004 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PFN2(NM_002628.4) - SHR108066 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PFN2(NM_053024.3) - SHR108150 from Creative biogene Category siRNA Species Reactivities Human

PFN2 shRNA Plasmid (Human) - CHH3486 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PFN2 miRNA 3'UTR clone - MiUTR1H-07805 from Creative biogene Species Reactivities Human

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