WAS

Gene Symbol	WAS
Entrez Gene	7454
Alt Symbol	IMD2, SCNX, THC, THC1, WASP, WASPA
Species	Human
Gene Type	protein-coding
Description	Wiskott-Aldrich syndrome
Other Description	eczema-thrombocytopenia|thrombocytopenia 1 (X-linked)|wiskott-Aldrich syndrome protein
Swissprots	Q9UNJ9 Q9BU11 P42768
Accessions	AAA60381 AAD26691 CAJ30264 EAW50758 EAW50759 P42768 BC002961 AAH02961 BC012738 AAH12738 BI910072 CF529565 EU176449 ABW03900 U12707 AAA62663 U19927 AAC50140 XM_011543977 XP_011542279 NM_000377 NP_000368
Function	Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. {ECO:0000269|PubMed:12235133, ECO:0000269|PubMed:16275905, ECO:0000269|PubMed:18650809}.
Subcellular Location	Cytoplasm, cytoskeleton.
Tissue Specificity	Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen. {ECO:0000269|PubMed:8069912}.
Top Pathways	Fc gamma R-mediated phagocytosis, Choline metabolism in cancer, Salmonella infection, Bacterial invasion of epithelial cells, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

WASP CRISPR/Cas9 KO Plasmid (h) - sc-400712 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP HDR Plasmid (h) - sc-400712-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP Double Nickase Plasmid (h) - sc-400712-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP Double Nickase Plasmid (h2) - sc-400712-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP CRISPR Activation Plasmid (h) - sc-400712-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP CRISPR Activation Plasmid (h2) - sc-400712-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP Lentiviral Activation Particles (h) - sc-400712-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP Lentiviral Activation Particles (h2) - sc-400712-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP siRNA (h) - sc-29525 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

WASP shRNA Plasmid (h) - sc-29525-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

WASP shRNA (h) Lentiviral Particles - sc-29525-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

WASP RNAi - H00007454-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU145111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22775 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22775 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1175 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

WAS siRNA (Human) - CRH5099 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

WAS - MBS8211361 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

WASP CRISPR/Cas9 KO Plasmid (h2) - sc-400712-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

WASP HDR Plasmid (h2) - sc-400712-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human WAS (NM_000377.2) - SHH445588 from Creative biogene Category siRNA Species Reactivities Human

Human WAS siRNA - orb265601 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

WAS shRNA Plasmid (Human) - CHH5099 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

WAS miRNA 3'UTR clone - MiUTR3H-02731 from Creative biogene Species Reactivities Human

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