TMPRSS2

Gene Symbol	TMPRSS2
Entrez Gene	7113
Alt Symbol	PP9284, PRSS10
Species	Human
Gene Type	protein-coding
Description	transmembrane protease, serine 2
Other Description	epitheliasin|serine protease 10|transmembrane protease serine 2
Swissprots	D3DSJ2 F8WES1 B7Z459 O15393 B2R8E5 Q6GTK7 A8K6Z8 Q9BXX1
Accessions	EAX09596 EAX09597 EAX09598 EAX09599 O15393 AA904080 AF123453 AAD37117 AF270487 AAK29280 AF318374 AAL55881 AF329454 AAK53559 AK123948 AK222784 BAD96504 AK291813 BAF84502 AK296860 BAH12445 AK313338 BAG36142 BC015819 BC035623 BC051839 AAH51839 BP276431 DC382934 DQ204771 EU090249 HM245389 HM245390 HQ448630 ADQ33108 U75329 AAC51784 XM_005261043 XP_005261100 XM_011529731 XP_011528033 XM_011529732 XP_011528034 XM_011529733 XP_011528035 NM_001135099 NP_001128571 NM_005656 NP_005647
Function	Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); inv
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.
Tissue Specificity	Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420}.
Top Pathways	Influenza A, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TMPRSS2 / Epitheliasin ELISA Kit (Sandwich ELISA) - LS-F6456 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.059 ng/ml Range 0.156-10 ng/ml

Mouse TMPRSS2 / Epitheliasin ELISA Kit (Sandwich ELISA) - LS-F8899 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.156-10 ng/ml

Transmembrane Protease, Serine 2, TMPRSS2, Human, ELISA Kit - E-EL-H1418 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Transmembrane Protease, Serine 2 (TMPRSS2), Human, ELISA Kit - SEC795Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.056ng/mL Range 0.156-10ng/mL

Transmembrane Protease, Serine 2, TMPRSS2, Rabbit, ELISA Kit - E-EL-RB1166 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Transmembrane Protease, Serine 2, TMPRSS2, Chicken, ELISA Kit - E-EL-Ch0028 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Transmembrane Protease, Serine 2, TMPRSS2, Porcine, ELISA Kit - E-EL-P0481 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Transmembrane Protease, Serine 2, TMPRSS2, Guinea Pig, ELISA Kit - E-EL-GP1138 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Transmembrane Protease, Serine 2, TMPRSS2, Monkey, ELISA Kit - E-EL-MK0814 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human TMPRSS2(Transmembrane Protease, Serine 2) ELISA Kit - E-EL-H1418 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human TMPRSS2 (Transmembrane Protease, Serine 2) CLIA Kit - E-CL-H0915 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

TMPRSS2, ELISA Kit - MBS2510085 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156--10ng/mL

TMPRSS2, ELISA Kit - MBS2508569 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TMPRSS2, ELISA Kit - MBS2503272 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

TMPRSS2, ELISA Kit - MBS2508193 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

TMPRSS2, ELISA Kit - MBS2514610 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

TMPRSS2, ELISA Kit - MBS2508512 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Transmembrane Protease, Serine 2, ELISA Kit - MBS105234 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS047405 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS072795 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS051555 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS102511 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS062078 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

transmembrane protease, serine 2, ELISA Kit - MBS2602912 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Transmembrane Protease, Serine 2, ELISA Kit - MBS063742 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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