TMPRSS2

Gene Symbol	TMPRSS2
Entrez Gene	7113
Alt Symbol	PP9284, PRSS10
Species	Human
Gene Type	protein-coding
Description	transmembrane protease, serine 2
Other Description	epitheliasin|serine protease 10|transmembrane protease serine 2
Swissprots	D3DSJ2 F8WES1 B7Z459 O15393 B2R8E5 Q6GTK7 A8K6Z8 Q9BXX1
Accessions	EAX09596 EAX09597 EAX09598 EAX09599 O15393 AA904080 AF123453 AAD37117 AF270487 AAK29280 AF318374 AAL55881 AF329454 AAK53559 AK123948 AK222784 BAD96504 AK291813 BAF84502 AK296860 BAH12445 AK313338 BAG36142 BC015819 BC035623 BC051839 AAH51839 BP276431 DC382934 DQ204771 EU090249 HM245389 HM245390 HQ448630 ADQ33108 U75329 AAC51784 XM_005261043 XP_005261100 XM_011529731 XP_011528033 XM_011529732 XP_011528034 XM_011529733 XP_011528035 NM_001135099 NP_001128571 NM_005656 NP_005647
Function	Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); inv
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.
Tissue Specificity	Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420}.
Top Pathways	Influenza A, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TMPRSS2 protein fragment - ab112364 from Abcam Category Protein Source Wheat germ Species Human

TMPRSS2 / Epitheliasin Antibody Blocking Peptide - LS-E8903 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TMPRSS2 / Epitheliasin Antibody Blocking Peptide - LS-E8904 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TMPRSS2 / Epitheliasin Antibody Blocking Peptide - LS-E26546 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TMPRSS2 Protein - H00007113-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human TMPRSS2 Protein - H00007113-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TMPRSS2-Antibody-Center-Blocking-Peptide - BP7377c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TMPRSS2-Antibody-N-term-Blocking-Peptide - BP7377a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TMPRSS2 blocking peptide - GTX88625-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Goat anti TMPRSS2 antibody Immunizing peptide - orb50497 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

Human TMPRSS2 Protein - abx069446 from Abbexa Category Protein Source E.coli Species Human

TMPRSS2 Peptide - AC21-1383-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TMPRSS2 - H00007113-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TMPRSS2 - H00007113-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TMPRSS2 - H00007113-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TMPRSS2 - H00007113-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Transmembrane Protease, Serine 2 (TMPRSS2), Human - 20-8582 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

TMPRSS2 Peptide - 46-908P from ProSci Category Peptide Species Human

TMPRSS2 fusion protein - ag6452 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TMPRSS2 fusion protein - ag0435 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

TMPRSS2 fusion protein - Ag5824 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human TMPRSS2 - TMPRSS2-30144TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Transmembrane Protease, Serine 2 (TMPRSS2) - RPC795Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Transmembrane Protease, Serine 2 (TMPRSS2) - RPC795Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Transmembrane Protease, Serine 2 (TMPRSS2) - RPC795Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

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