TMPRSS2

Gene Symbol	TMPRSS2
Entrez Gene	7113
Alt Symbol	PP9284, PRSS10
Species	Human
Gene Type	protein-coding
Description	transmembrane protease, serine 2
Other Description	epitheliasin|serine protease 10|transmembrane protease serine 2
Swissprots	D3DSJ2 F8WES1 B7Z459 O15393 B2R8E5 Q6GTK7 A8K6Z8 Q9BXX1
Accessions	EAX09596 EAX09597 EAX09598 EAX09599 O15393 AA904080 AF123453 AAD37117 AF270487 AAK29280 AF318374 AAL55881 AF329454 AAK53559 AK123948 AK222784 BAD96504 AK291813 BAF84502 AK296860 BAH12445 AK313338 BAG36142 BC015819 BC035623 BC051839 AAH51839 BP276431 DC382934 DQ204771 EU090249 HM245389 HM245390 HQ448630 ADQ33108 U75329 AAC51784 XM_005261043 XP_005261100 XM_011529731 XP_011528033 XM_011529732 XP_011528034 XM_011529733 XP_011528035 NM_001135099 NP_001128571 NM_005656 NP_005647
Function	Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); inv
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.
Tissue Specificity	Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420}.
Top Pathways	Influenza A, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-TMPRSS2-cDNA-Clone - DC07881 from Abgent, a WuXi AppTec company Prices $664.20 Sizes 10 µg Species Human Accession BC051839

TMPRSS2 - MBS1268467 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC051839

Human TMPRSS2 cDNA clone(NM_001135099.1) - CDFH019963 from Creative Biomart Species Human Accession NM_001135099.1

Human TMPRSS2 ORF clone(NM_005656.3) - CDCL186513 from Creative Biomart Species Human Accession NM_005656.3

Human TMPRSS2 ORF Clone(NM_001135099.1) - CDCL179150 from Creative Biomart Species Human Accession NM_001135099.1

Human TMPRSS2 ORF Clone(NM_001135099.1) - CDCR350224 from Creative Biomart Species Human Accession NM_001135099.1

Human TMPRSS2 ORF Clone(NM_001135099.1) - CDCR350228 from Creative Biomart Species Human Accession NM_001135099.1

human TMPRSS2 ORF clone - CDCH093220 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093221 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093222 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093223 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093224 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093225 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093226 from Creative Biomart Species Human Accession NM_001135099

human TMPRSS2 ORF clone - CDCH093227 from Creative Biomart Species Human Accession NM_001135099

Human TMPRSS2 Gene ORF cDNA clone in cloning vector - HG13070-G from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13070-ACG from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13070-CY from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13070-NF from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13070-NY from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13070-NM from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13070-CF from Sino Biological Species Human

Human TMPRSS2 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG13070-G-N from Sino Biological Species Human Accession NM_005656.3

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, N-His tag - HG13070-NH from Sino Biological Species Human

Human TMPRSS2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13070-CM from Sino Biological Species Human

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