| Gene Symbol |
TMPRSS2
|
| Entrez Gene |
7113
|
| Alt Symbol |
PP9284, PRSS10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transmembrane protease, serine 2
|
| Other Description |
epitheliasin|serine protease 10|transmembrane protease serine 2
|
| Swissprots |
D3DSJ2 F8WES1 B7Z459 O15393 B2R8E5 Q6GTK7 A8K6Z8 Q9BXX1
|
| Accessions |
EAX09596 EAX09597 EAX09598 EAX09599 O15393 AA904080 AF123453 AAD37117 AF270487 AAK29280 AF318374 AAL55881 AF329454 AAK53559 AK123948 AK222784 BAD96504 AK291813 BAF84502 AK296860 BAH12445 AK313338 BAG36142 BC015819 BC035623 BC051839 AAH51839 BP276431 DC382934 DQ204771 EU090249 HM245389 HM245390 HQ448630 ADQ33108 U75329 AAC51784 XM_005261043 XP_005261100 XM_011529731 XP_011528033 XM_011529732 XP_011528034 XM_011529733 XP_011528035 NM_001135099 NP_001128571 NM_005656 NP_005647
|
| Function |
Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); inv
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.
|
| Tissue Specificity |
Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420}.
|
| Top Pathways |
Influenza A, Transcriptional misregulation in cancer
|
