TMPRSS2

Gene Symbol TMPRSS2
Entrez Gene 7113
Alt Symbol PP9284, PRSS10
Species Human
Gene Type protein-coding
Description transmembrane protease, serine 2
Other Description epitheliasin|serine protease 10|transmembrane protease serine 2
Swissprots D3DSJ2 F8WES1 B7Z459 O15393 B2R8E5 Q6GTK7 A8K6Z8 Q9BXX1
Accessions EAX09596 EAX09597 EAX09598 EAX09599 O15393 AA904080 AF123453 AAD37117 AF270487 AAK29280 AF318374 AAL55881 AF329454 AAK53559 AK123948 AK222784 BAD96504 AK291813 BAF84502 AK296860 BAH12445 AK313338 BAG36142 BC015819 BC035623 BC051839 AAH51839 BP276431 DC382934 DQ204771 EU090249 HM245389 HM245390 HQ448630 ADQ33108 U75329 AAC51784 XM_005261043 XP_005261100 XM_011529731 XP_011528033 XM_011529732 XP_011528034 XM_011529733 XP_011528035 NM_001135099 NP_001128571 NM_005656 NP_005647
Function Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L- independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); inv
Subcellular Location Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.
Tissue Specificity Highly expressed in prostate epithelial cells and in prostate cancers. Expressed in type II pneumocytes in the lung (at protein level). Expressed strongly in small intestine. Also expressed in colon, stomach and salivary gland. {ECO:0000269|PubMed:11169526, ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21325420}.
Top Pathways Influenza A, Transcriptional misregulation in cancer

TMPRSS2 (H-50) - sc-33533 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TMPRSS2 (H-50): sc-33533. Western blot analysis of TMPRSS2 expression in non-transfected: sc-117752 (A) and mouse TMPRSS2 transfected: sc-124196 (B) 293T whole cell lysates.

TMPRSS2 (N-13) - sc-19686 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TMPRSS2 (P5H9-A3) - sc-101847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-TMPRSS2 antibody - ab56111 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab56111 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab56111, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TMPRSS2 antibody - ab56112 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TMPRSS2 antibody (ab56112) at 1/1000 dilution + Whole cell lysate from human colon cancer SW620 cells

Anti-TMPRSS2 antibody - ab82146 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-TMPRSS2 antibody (ab82146) at 0.1 µg/ml + human pancreas lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-TMPRSS2 antibody - ab167671 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-TMPRSS2 antibody (ab167671) at 1 µg/mlLane 1 : TMPRSS2 transfected 293T cell lysate Lane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.

Anti-TMPRSS2 antibody [EPR3861] - ab92323 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3861
All lanes : Anti-TMPRSS2 antibody [EPR3861] (ab92323) at 1/1000 dilutionLane 1 : Human prostate lysateLane 2 : Human small intestine lysateLane 3 : LNCaP cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/1000 dilution

Anti-TMPRSS2 antibody [EPR3861] (HRP) - ab199095 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3861
Anti-TMPRSS2 antibody [EPR3861] (HRP) (ab199095) at 1/5000 dilution + Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276) at 10 µgdeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TMPRSS2 antibody [EPR3862] - ab109131 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3862
ab109131 staining TMPRSS2 in the HT-29 cell line by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with 4% Paraformaldehyde permeabilized with 0.1% Triton X-100. Samples were incubated with primary antibody (1/150). ab150077(1/500) an Alexa Fluor®488-conjugated Goat anti-rabbit IgG was used as the secondary antibody. Nuclei were counterstained with DAPI.

Anti-TMPRSS2 antibody - Aminoterminal end - ab56110 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TMPRSS2 antibody - Aminoterminal end (ab56110) at 1/1000 dilutionLane 1 : Mouse Stomach LystaeLane 2 : Mouse Stomach LystaeLane 3 : DUC26 Cell LysateLane 4 : DUC26 Cell LysateLane 5 : DUC26 Cell LysateLane 6 : HEK293 Cell LysateLane 7 : HEK293 Cell Lysate

Anti-TMPRSS2 antibody - C-terminal - ab187346 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TMPRSS2 antibody - C-terminal (ab187346) at 1/1000 dilutionLane 1 : Mouse brain lysateLane 2 : Mouse thymus lysate

Anti-TMPRSS2 antibody - N-terminal - ab187349 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TMPRSS2 antibody - N-terminal (ab187349) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse thymus total cell extract

Anti-TMPRSS2 / Epitheliasin Antibody (N-Terminus) - LS-C345748 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TMPS2 Antibody with human Fetal Lung lysate.

Anti-TMPRSS2 / Epitheliasin Antibody (Internal, clone EPR3861) - LS-C105697 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR3861
IHC of paraffin-embedded human prostatic adenocarcinoma using anti-TMPRSS2 antibody.

Anti-TMPRSS2 / Epitheliasin Antibody (aa314-343) - LS-C100564 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of TMPRSS2 antibody in HepG2 cell line lysates (35 ug/lane). TMPRSS2 (arrow) was detected using the purified antibody.

Anti-TMPRSS2 / Epitheliasin Antibody (Extracellular Domain, clone EPR3862) IHC-plus™ - LS-B8961 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3862
Anti-TMPRSS2 / Epitheliasin antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-TMPRSS2 / Epitheliasin Antibody (aa1-30) - LS-C100563 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TMPRSS2 Antibody (RB18784) IHC of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-TMPRSS2 / Epitheliasin Antibody (aa284-492, Biotin) - LS-C300336 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS2 / Epitheliasin Antibody (aa284-492, FITC) - LS-C303304 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS2 / Epitheliasin Antibody (aa100-470) - LS-C311464 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS2 / Epitheliasin Antibody - LS-C342249 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TMPRSS2 / Epitheliasin Antibody (clone 2F4) - LS-C198350 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F4
Detection limit for recombinant GST tagged TMPRSS2 is approximately 3 ng/ml as a capture antibody.

Anti-TMPRSS2 / Epitheliasin Antibody (aa284-492) - LS-C296775 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant TMPRSS2 / Epitheliasin.

Anti-TMPRSS2 / Epitheliasin Antibody (C-Terminus) - LS-C345448 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of TMPS2 Antibody with human Fetal Liver lysate.
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